Exploration of Asthma & Allergy

Table 7. Simplified EATERS-X history: focus on different categories of CMA.

Category	IgE-mediated CMA	Non-IgE-mediated CMA	Mixed IgE-mediated CMA	FPIES
Environment	Infants < 12 months	Infants < 6 months	Infants < 12 months, often with eczema	Infancy, usually < 12 months
Feeding	Breast or formula fed	Breast or formula fed	Formula or solids	Formula or solids
Allergen	Cow’s milk protein	Cow’s milk protein (direct or via breast milk)	Cow’s milk protein	Cow’s milk protein
Timing	Immediate (< 2 hours)	Delayed (up to 48 hours)	Immediate and/or delayed	1–4 hours (up to 6 hours)
Exposure	Direct ingestion	Direct or indirect (breast milk)	Direct ingestion	Direct ingestion
Reproducibility	Symptoms resolve on exclusion and recur on re-exposure	Symptoms resolve on exclusion and recur on re-exposure	Symptoms resolve on exclusion and recur on re-exposure	Symptoms worsen with repeated exposure; re-challenge supervised
Symptoms	Acute allergic symptoms	Delayed gastrointestinal and skin symptoms	A combination of acute and delayed symptoms	Severe gastrointestinal ± systemic symptoms
Extra (Treatment)	Managed as an IgE allergy	Managed by dietary exclusion	Managed by dietary exclusion	Acute management; specialist follow-up

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CMA: cow’s milk allergy; FPIES: food protein-induced enterocolitis syndrome.

Supplementary materials

The supplementary table for this article is available at: https://www.explorationpub.com/uploads/Article/file/1009106_sup_1.pdf.

Declarations

Author contributions

MLQ: Data curation, Formal analysis, Methodology, Visualization, Writing—original draft, Writing—review & editing. IR, AMON, and SAD: Resources, Writing—review & editing. MG and RM: Writing—review & editing. MEL: Conceptualization, Supervision, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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