Exploration of Drug Science

Table 2. Summary of monovalent second mitochondria-derived activator of caspases (SMAC) mimetics. Monovalent SMAC mimetics in clinical trials and monovalent SMAC mimetics are presented in literature but not discussed in this review

Compound	Type of cancer	Clinical trials	References
GDC-0152^※	Glioblastoma, leukaemia, and osteosarcoma	NCT00977067	[125–127]
GDC-0917	Lymphoma	NCT01226277	[119]
LCL-161^※	Leukaemia	NCT03111992	[128]
SM-406/AT-406^※	Solid tumours, lymphomas, and acute myelogenous leukaemia	NCT01078649	[121]
LBW242	Multiple myeloma	-	[129]
MV1	Breast carcinoma	-	[130]
CS3	Melanoma and breast carcinoma	-	[131]
Aza-phenylalanine 7	Breast cancer	-	[132]
Compound 1	Breast cancer	-	[117]
Compound 2	Leukaemia	-	[133]
SM114	Breast cancer	-	[134]
SM130	Breast cancer	-	[134]

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^※ Drugs in clinical trial for different cancer types; -: no data

Declarations

Author contributions

AV and RDM: Conceptualization, Validation, Writing—original draft, Writing—review & editing, Supervision. DL: Validation, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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