Exploration of Drug Science

Table 1. Specifications of the five Fuc-specific lectins [163]

Number	Lectin	Preferred binding Fuc	Substances used for elution
1	Lens culinaris agglutinin	Fucα1-6GlcNAc	methyl α-D-mannoside
2	Lotus tetragonolobus lectin	Fucα1-3GlcNAc, Fucα1-3 (Lewis X and Y), sLeX	L-Fuc
3	Ulex europaeus lectin I	Fucα1-2Gal β1-4Glc(NAc)	L-Fuc
4	Aleuria aurantia lectin	Fucα1-2, Fucα1-3/4, Fucα1-6GlcNAc	L-Fuc
5	Aspergillus oryzae lectin	Fucα1-2, Fucα1-3/4, Fucα1-6GlcNAc	L-Fuc

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Note. Adapted from “Comparison of fucose-specific lectins to improve quantitative AFP-L3 assay for diagnosing hepatocellular carcinoma using mass spectrometry,” by Lee J, Yeo I, Kim Y, Shin D, Kim J, Kim Y, et al. J Proteome Res. 2022;21:1548–57 (https://pubs.acs.org/doi/10.1021/acs.jproteome.2c00196). © 2022, American Chemical Society.

Declarations

Author contributions

QC: Conceptualization, Writing—original draft, Writing—review & editing. HL: Writing—original draft, Writing—review & editing. XL: Conceptualization, Writing—original draft, Writing—review & editing, Supervision.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

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Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

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Funding

The work was funded by the Laboratory for Synthetic Chemistry and Chemical Biology Limited under the Health@InnoHK Program by the Innovation and Technology Commission. The Funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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