Compound prevalence based on published GC-MS analyses; exact composition may vary due to geographical, seasonal, and methodological factors. While all listed species are sold as “cedarwood oils,” their chemical profiles and biological activities vary considerably. Oils from T. plicata contain high levels of thujone, a neurotoxic ketone, and should not be used in cosmetics or therapeutic applications [17]. CWO: cedarwood essential oil.
Declarations
Author contributions
SDG: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Validation, Data curation, Formal analysis, Resources, Project administration, Methodology, Supervision. The author read and approved the submitted version.
Conflicts of interest
The author declares that there are no conflicts of interest.
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References
Gonçalves S, Marques P, Matos RS. Exploring Aromatherapy as a Complementary Approach in Palliative Care: A Systematic Review.J Palliat Med. 2024;27:1247–66. [DOI] [PubMed]
Ramadass M, Thiagarajan P. Importance and Applications of Cedar oil.Rese J Pharm Technol. 2015;8:1714. [DOI]
Stamova S, Ermenlieva N, Tsankova G, Georgieva E. Antimicrobial Activity of Lavender Essential Oil from Lavandula angustifolia Mill.: In Vitro and In Silico Evaluation.Antibiotics (Basel). 2025;14:656. [DOI] [PubMed] [PMC]
Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties.Clin Microbiol Rev. 2006;19:50–62. [DOI] [PubMed] [PMC]
Adams RP, Li S. The Botanical Source of Chinese Cedarwood Oil: Cupressus funebris or Cupressaceae Species?J Essent Oil Res. 2008;20:235–42. [DOI]
Chang K, Huang X, Chang JT, Huang YC, Lo WS, Hsiao CY, et al. Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.J Nat Prod. 2020;83:3021–9. [DOI] [PubMed]
National Toxicology Program. Toxicity studies of cedarwood oil (Virginia) administered dermally to F344/N rats and B6C3F1/N mice.Toxic Rep Ser. 2016:NTP–TOX. [DOI] [PubMed] [PMC]
Hartley N, McLachlan CS. Aromas Influencing the GABAergic System.Molecules. 2022;27:2414. [DOI] [PubMed] [PMC]
Jeong HU, Kwon SS, Kong TY, Kim JH, Lee HS. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes.J Toxicol Environ Health A. 2014;77:1522–32. [DOI] [PubMed]
Zheljazkov VD, Kacaniova M, Dincheva I, Radoukova T, Semerdjieva IB, Astatkie T, et al. Essential oil composition, antioxidant and antimicrobial activity of the galbuli of six juniper species.Ind Crops Prod. 2018;124:449–58. [DOI]
Mun SP, Prewitt L. Antifungal Activity of Organic Extracts from Juniperus virginiana Heartwood against Wood Decay Fungi.For Prod J. 2011;61:443–9. [DOI]
Sadgrove NJ, Senbill H, Van Wyk BE, Greatrex BW. New Labdanes with Antimicrobial and Acaricidal Activity: Terpenes of Callitris and Widdringtonia (Cupressaceae).Antibiotics (Basel). 2020;9:173. [DOI] [PubMed] [PMC]
Tumen I, Eller FJ, Clausen CA, Teel JA. Antifungal activity of heartwood extracts from three Juniperus species.BioResources. 2013;8:12–20. [DOI]
Barrero AF, Quílez del Moral JF, Lara A, Herrador MM. Antimicrobial activity of sesquiterpenes from the essential oil of Juniperus thurifera.Planta Med. 2005;71:67–71. [DOI] [PubMed]
Sühring R, Chen CE, McLachlan MS, MacLeod M. Bioconcentration of cedarwood oil constituents in rainbow trout.Environ Sci Process Impacts. 2021;23:689–98. [DOI] [PubMed]
Zrira S, Ghanmi M. Chemical Composition and Antibacterial Activity of the Essential of Cedrus atlantica (Cedarwood oil).J Essent Oil Bear Plants. 2016;19:1267–72. [DOI]
Zámboriné Németh É, Thi Nguyen H. Thujone, a widely debated volatile compound: What do we know about it?Phytochem Rev. 2020;19:405–23. [DOI]
Belkacem N, Khettal B, Hudaib M, Bustanji Y, Abu-Irmaileh B, Amrine CSM. Antioxidant, antibacterial, and cytotoxic activities of Cedrus atlantica organic extracts and essential oil.Eur J Integr Med. 2021;42:101292. [DOI]
Gonçalves S, Peixoto F, Schoss K, Glavač NK, Gaivão I. Elderberry Hydrolate: Exploring Chemical Profile, Antioxidant Potency and Antigenotoxicity for Cosmetic Applications.Appl Sci. 2024;14:6338. [DOI]
Eller FJ, Taylor SL. Pressurized fluids for extraction of cedarwood oil from Juniperus virginianna.J Agric Food Chem. 2004;52:2335–8. [DOI] [PubMed]
Marčac N, Balbino S, Tonković P, Medved AM, Cegledi E, Dragović S, et al. Hydrodistillation and Steam Distillation of Fennel Seeds Essential Oil: Parameter Optimization and Application of Cryomilling Pretreatment.Processes. 2023;11:2354. [DOI]
Capuzzo A, Maffei ME, Occhipinti A. Supercritical fluid extraction of plant flavors and fragrances.Molecules. 2013;18:7194–238. [DOI] [PubMed] [PMC]
Prabuseenivasan S, Jayakumar M, Ignacimuthu S. In vitro antibacterial activity of some plant essential oils.BMC Complement Altern Med. 2006;6:39. [DOI] [PubMed] [PMC]
Abd Rashed A, Rathi DG, Ahmad Nasir NAH, Abd Rahman AZ. Antifungal Properties of Essential Oils and Their Compounds for Application in Skin Fungal Infections: Conventional and Nonconventional Approaches.Molecules. 2021;26:1093. [DOI] [PubMed] [PMC]
Hartman K, Świerczyńska M, Wieczorek A, Baszuk P, Wojciechowska-Koszko I, Garbacz K, et al. Preliminary Evaluation of the Synergistic Antibacterial Effects of Selected Commercial Essential Oil Compounds Against Methicillin-Resistant Staphylococcus aureus ATCC 43300.Antibiotics (Basel). 2025;14:733. [DOI] [PubMed] [PMC]
Zhang K, Yao L. The anxiolytic effect of Juniperus virginiana L. essential oil and determination of its active constituents.Physiol Behav. 2018;189:50–8. [DOI] [PubMed]
Kagawa D, Jokura H, Ochiai R, Tokimitsu I, Tsubone H. The sedative effects and mechanism of action of cedrol inhalation with behavioral pharmacological evaluation.Planta Med. 2003;69:637–41. [DOI] [PubMed]
Hedigan F, Sheridan H, Sasse A. Benefit of inhalation aromatherapy as a complementary treatment for stress and anxiety in a clinical setting - A systematic review.Complement Ther Clin Pract. 2023;52:101750. [DOI] [PubMed]
Egbuta MA, McIntosh S, Waters DLE, Vancov T, Liu L. In Vitro Anti-Inflammatory Activity of Essential Oil and β-Bisabolol Derived from Cotton Gin Trash.Molecules. 2022;27:526. [DOI] [PubMed] [PMC]
Dontje AEWK, Schuiling-Veninga CCM, van Hunsel FPAM, Ekhart C, Demirci F, Woerdenbag HJ. The Therapeutic Potential of Essential Oils in Managing Inflammatory Skin Conditions: A Scoping Review.Pharmaceuticals (Basel). 2024;17:571. [DOI] [PubMed] [PMC]
Javed S, Mangla B, Salawi A, Sultan MH, Almoshari Y, Ahsan W. Essential Oils as Dermocosmetic Agents, Their Mechanism of Action and Nanolipidic Formulations for Maximized Skincare.Cosmetics. 2024;11:210. [DOI]
Nurzyńska-Wierdak R, Pietrasik D, Walasek-Janusz M. Essential Oils in the Treatment of Various Types of Acne-A Review.Plants (Basel). 2022;12:90. [DOI] [PubMed] [PMC]
Patten AM, Vassão DG, Wolcott MP, Davin LB, Lewis NG. Trees: A Remarkable Biochemical Bounty. In: Liu HW, Mander L, editors. Comprehensive Natural Products II. Oxford: Elsevier; 2010. pp. 1173–296. [DOI]
Yu BS, Kim SS, Yun YH, Kim KY. A Cytotoxicity of Carrier Oil and Essential Oils on Cells by Using of Aromatherapy.Korean J Hum Ecol. 2008;17:1027–35. [DOI]
Diogo Gonçalves S. Pruritus in Palliative Care: A Narrative Review of Essential Oil-Based Strategies to Alleviate Cutaneous Discomfort.Diseases. 2025;13:232. [DOI] [PubMed] [PMC]
Gonçalves S, Fernandes L, Caramelo A, Martins M, Rodrigues T, Matos RS. Soothing the Itch: The Role of Medicinal Plants in Alleviating Pruritus in Palliative Care.Plants (Basel). 2024;13:3515. [DOI] [PubMed] [PMC]
Flor-Weiler LB, Behle RW, Eller FJ, Muturi EJ, Rooney AP. Repellency and toxicity of a CO2-derived cedarwood oil on hard tick species (Ixodidae).Exp Appl Acarol. 2022;86:299–312. [DOI] [PubMed] [PMC]
United States Environmental Protection Agency. Active Ingredients Eligible for Minimum Risk Pesticide Products. Washington (USA): Office of Chemical Safety and Pollution Prevention; 2015.
Belounis Y, Moualek I, Sebbane H, Ait Issad H, Saci S, Saoudi B, et al. Potential Natural Antioxidant and Anti-Inflammatory Properties of Carthamus caeruleus L. Root Aqueous Extract: An In Vitro Evaluation.Processes. 2025;13:878. [DOI]
Câmara JS, Perestrelo R, Ferreira R, Berenguer CV, Pereira JAM, Castilho PC. Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications-A Comprehensive Overview.Molecules. 2024;29:3861. [DOI] [PubMed] [PMC]
Emami SA, Asgary S, Naderi GA, Shams Ardekani MR, Kasher T, Aslani S, et al. Antioxidant activities of Juniperus foetidissima essential oils against several oxidative systems.Rev Bras Farmacogn. 2011;21:627–34. [DOI]
López-Romero D, Izquierdo-Vega JA, Morales-González JA, Madrigal-Bujaidar E, Chamorro-Cevallos G, Sánchez-Gutiérrez M, et al. Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin.Nutrients. 2018;10:1954. [DOI] [PubMed] [PMC]
Nakadate K, Ito N, Kawakami K, Yamazaki N. Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.Int J Mol Sci. 2025;26:5206. [DOI] [PubMed] [PMC]
Huang K, Liu R, Zhang Y, Guan X. Characteristics of two cedarwood essential oil emulsions and their antioxidant and antibacterial activities.Food Chem. 2021;346:128970. [DOI] [PubMed]
Caballero-Gallardo K, Quintero-Rincón P, Olivero-Verbel J. Aromatherapy and Essential Oils: Holistic Strategies in Complementary and Alternative Medicine for Integral Wellbeing.Plants (Basel). 2025;14:400. [DOI] [PubMed] [PMC]
Die Trill M. Anxiety and sleep disorders in cancer patients.EJC Suppl. 2013;11:216–24. [DOI] [PubMed] [PMC]
Johnson SA, Rodriguez D, Allred K. A Systematic Review of Essential Oils and the Endocannabinoid System: A Connection Worthy of Further Exploration.Evid Based Complement Alternat Med. 2020;2020:8035301. [DOI] [PubMed] [PMC]
Pérez GS, Zavala SM, Arias GL, Ramos LM. Anti-inflammatory Activity of Some Essential Oils.J Essent Oil Res. 2011;23:38–44. [DOI]
Khamis EAR, Abu Raddaha AH, Nafae WH, Al-Sabeely AA, Ebrahim EE, Elhadary SM. Effectiveness of Aromatherapy in Early Palliative Care for Oncology Patients: Blind Controlled Study.Asian Pac J Cancer Prev. 2023;24:2729–39. [DOI] [PubMed] [PMC]
Farrar AJ, Farrar FC. Clinical Aromatherapy.Nurs Clin North Am. 2020;55:489–504. [DOI] [PubMed] [PMC]
Gonçalves S, Martins M, Caramelo A, Magalhães B, Matos RS. Exploring skin disorders in palliative care: a systematic review.Rev Bras Farmacogn. 2024;19:133–43. [DOI]
Gonçalves S, Gaivão I. Natural Ingredients in Skincare: A Scoping Review of Efficacy and Benefits.Biomed Biopharm Res. 2023;20:143–60. [DOI]
Zhang Y, Heinemann N, Rademacher F, Darvin ME, Raab C, Keck CM, et al. Skin Care Product Rich in Antioxidants and Anti-Inflammatory Natural Compounds Reduces Itching and Inflammation in the Skin of Atopic Dermatitis Patients.Antioxidants (Basel). 2022;11:1071. [DOI] [PubMed] [PMC]
Sattayakhom A, Wichit S, Koomhin P. The Effects of Essential Oils on the Nervous System: A Scoping Review.Molecules. 2023;28:3771. [DOI] [PubMed] [PMC]
Takeda A, Watanuki E, Koyama S. Effects of Inhalation Aromatherapy on Symptoms of Sleep Disturbance in the Elderly with Dementia.Evid Based Complement Alternat Med. 2017;2017:1902807. [DOI] [PubMed] [PMC]
Bahr TA, Rodriguez D, Beaumont C, Allred K. The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review.Evid Based Complement Alternat Med. 2019;2019:6216745. [DOI] [PubMed] [PMC]
Johnson W Jr. Final report on the safety assessment of Juniperus communis Extract, Juniperus oxycedrus Extract, Juniperus oxycedrus Tar, Juniperus phoenicea extract, and Juniperus virginiana Extract.Int J Toxicol. 2001;20:41–56. [DOI] [PubMed]
Catlin NR, Herbert R, Janardhan K, Hejtmancik MR, Fomby LM, Vallant M, et al. Dose-response assessment of the dermal toxicity of Virginia cedarwood oil in F344/N rats and B6C3F1/N mice.Food Chem Toxicol. 2016;98:159–68. [DOI] [PubMed] [PMC]
Paulsen E, Andersen KE. Patch testing with constituents of sesquiterpene lactone-containing mixes: time of application is important.Contact Dermatitis. 2012;66:354–5. [DOI] [PubMed]
Jovanović M, Poljacki M, Mimica-Dukić N, Boza P, Vujanović Lj, Duran V, et al. Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-allergic chronic inflammatory skin diseases.Contact Dermatitis. 2004;51:101–10. [DOI] [PubMed]
Wanwimolruk S, Prachayasittikul V. Cytochrome P450 enzyme mediated herbal drug interactions (Part 1).EXCLI J. 2014;13:347–91. [PubMed] [PMC]
Carpena M, Nuñez-Estevez B, Soria-Lopez A, Garcia-Oliveira P, Prieto MA. Essential Oils and Their Application on Active Packaging Systems: A Review.Resources. 2021;10:7. [DOI]
Office of the Prevention Pesticides And Toxic Substances. Wood Oils and Gums (Cedarwood Oil). USA: United States Environmental Protection Agency; 1993.