Exploration of Drug Science

Algorithm	Web address
NetMHC-4.0 [19, 20]	https://services.healthtech.dtu.dk/services/NetMHC-4.0/
PicPocket [21]	https://services.healthtech.dtu.dk/service.php?PickPocket-1.1
NetCTLpan-1.1 server [22]	https://services.healthtech.dtu.dk/services/NetCTLpan-1.1/ (discontinued)
NetMHCpan-4.1 [23]	https://services.healthtech.dtu.dk/services/NetMHCpan-4.1/
TepiTool [24]	http://tools.iedb.org/tepitool/
COVIDep [25]	https://covidep.ust.hk/

Declarations

Acknowledgments

We dedicate this publication to Dr. Manuel Elkin Patarroyo Murillo, who passed away on January 9th, 2025. He was a fundamental factor in the creation of our research group and supported training in the immunochemical area of the team, particularly in everything related to the chemical synthesis of peptides. He was also a great role model as a researcher who dedicated his life to generating well-being for the most vulnerable populations on the planet as a pioneer in the development of synthetic vaccines and the training of a very large group of scientists at the Colombian Institute of Immunology in Bogotá.

Author contributions

ON: Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization, Writing—original draft, Writing—review & editing. HB: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Resources, Validation, Visualization, Writing—original draft, Writing—review & editing. DP: Conceptualization, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing—original draft, Writing—review & editing. BAdN: Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing—original draft, Writing—review & editing. DOP: Data curation, Investigation, Methodology, Validation, Visualization, Writing—original draft, Writing—review & editing. FHP: Data curation, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing—original draft, Writing—review & editing. SL: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing—original draft, Writing—review & editing. All authors have read and agreed to the published version of the manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This article summarizes the research produced in the area of synthetic peptides with diagnostic value for infectious diseases, generated by several research projects that were approved by different bioethics committees that comply with international regulations to respect ethical standards related to studies with human beings. Regarding the non-published results for patients with HIV/AIDS, the Bioethics Committee of the Instituto Venezolano de Investigaciones Científicas (IVIC) approved the use of sera from patients in the project titled: “Viral hepatitis and AIDS: molecular characteristics of infections in Venezuela (G-2005000394)” at Meeting No. 1323 on May 20th, 2009. Similarly, the sera of patients with Helicobacter pylori infection were used with the consent of the Ethical Committee of the Instituto de Biomedicina on November 14th, 2006, with the project titled: “Immunological profile, genotype and pathologies associated with Helicobacter pylori in Venezuelan individuals”. This study complies with the 2024 Declaration of Helsinki.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

Funding

Funding was obtained via the following grants: Corporación Andina de Fomento (CAF) 1992; National Laboratory of Proteomics and Immunochemistry of Proteins [FONACIT-2005]; Melinda & Bill Gates Foundation 2017 project No. [OPP1151004]; FONACIT 2022–2024 project No. [20220PGP129]; FONACIT 2022–2024 project No. [20220PGP130]; FONACIT 2024–2026 project CFP No. [2024000297]; FONACIT project PEI No. [20122000815]; FONACIT 2022 project No. [20220PGP06]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

Publisher’s note

Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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