From:  A simple quantitative model for the prediction of exposure of renally excreted drugs in pregnant women: a comparison with whole body PBPK model

 Cmax values and ratio between non-pregnant/healthy volunteers and pregnant women [1623, 26]

DrugsPregnancyNon-pregnant, mg/LPregnant, mg/LRatio, preg/non-pregnant
Metformin3rd trimester1.61.140.71
Metformin10–14 weeks1.61.220.76
Metformin22–26 weeks1.61.060.66
Metformin34–38 weeks1.61.140.71
Digoxin3rd trimester1.1*0.8*0.73
Emtricitabine3rd trimester1.4**1.4**1.00
Emtricitabine28–38 weeks2.01.80.90
Emtricitabine31–38 weeks1.41.41.0
Cefradine (oral)13–33 weeks11.86.10.52
Oseltamivir carboxylateFirst trimester397*150*0.39
Oseltamivir carboxylateSecond trimester397*153*0.40
Oseltamivir carboxylateThird trimester397*198*0.52
Tenofovir38 weeks0.330.280.85

* Cmax: ng/mL. ** µg/mL