From:  A simple quantitative model for the prediction of exposure of renally excreted drugs in pregnant women: a comparison with whole body PBPK model

 AUC values and ratio between non-pregnant/healthy volunteers and pregnant women [16–23, 26]

DrugsPregnancyNon-pregnant, mg·hr/LPregnant, mg·hr/LRatio, preg/non-preg
Metformin3rd trimester9,804*6,9370.71
Metformin10–14 weeks9.86.50.66
Metformin22–26 weeks9.86.10.62
Metformin34–38 weeks9.86.90.70
Metformin26–38 weeks9.87.70.79
Metformin26–38 weeks9.911.91.20
Digoxin3rd trimester9.3*7.3*0.78
Emtricitabine3rd trimester9.7**8.0**0.82
Emtricitabine15–28 weeks9.88.40.86
Emtricitabine28–40 weeks9.88.20.84
Emtricitabine39 weeks9.88.30.85
Emtricitabine28–38 weeks13.09.60.74
Emtricitabine31–38 weeks9.78.00.82
Lamivudine36–40 weeks12.712.50.98
Ceftazidime29 weeks1501100.73
Ceftazidime39 weeks1501200.80
Cefuroxime30–37 weeks82420.51
Aztreonam25–30 weeks166970.58
Aztreonam25–30 weeks1661180.71
Ceftriaxone29 weeks1,5651,5881.01
Imipenem40 weeks33270.82
Imipenem40 weeks33130.39
Fluconazole30–37 weeks1751210.69
Cefazolin19–33 weeks110760.69
Cefuroxime11–35 weeks68420.62
Cefuroxime42 weeks68470.69
Cefradine (IV)10–29 weeks39240.62
Cefradine (oral)13–33 weeks32250.78
OseltamivirFirst trimester3,507*1,828*0.52
OseltamivirSecond trimester3,507*2,325*0.66
OseltamivirThird trimester3,507*2,367*0.67
AmoxicillinSecond trimester20**15.2**0.76
AmoxicillinThird trimester20**14.9**0.75
TenofovirThird trimester3.22.50.78
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* ng·hr/mL. ** µg·hr/mL