From:  A simple quantitative model for the prediction of exposure of renally excreted drugs in pregnant women: a comparison with whole body PBPK model

 Cmax and AUC values used from non-pregnant women/healthy volunteers to predict Cmax and AUC values in pregnant women

DrugsDose (mg), non-pregnantUnbound proteinNon-pregnantRef.
AUC, mg·hr/LCmax, mg/L
Metformin500 mg oral0.999,804**1,611*[16, 26]
Digoxin0.25 mg oral0.759.3**1.1*[16, 26]
Emtricitabine200 mg oral0.969.7**1.4*[16, 26]
Ceftazidime1,000 mg IV0.85150 NA[17]
Ceftazidime1,000 mg IV0.85150NA[17]
Cefuroxime750 mg IV0.6782NA[17]
Aztreonam1,000 mg IV0.44166NA[17]
Ceftriaxone2,000 mg IV0.0751,565 NA[17]
Imipenem500 mg IV0.8033NA[17]
Imipenem500 mg IV0.8033NA[17]
Fluconazole200 mg oral0.89175NA[17]
Acyclovir400 mg oral QD0.79****3.90.80[18, 26]
Emtricitabine200 mg QDss oral0.969.8NAFrom Vilade et al. in [18] and [26]
Emtricitabine200 mg QDss oral0.969.8NAFrom Vilade et al. in [18] and [26]
Emtricitabine200 mg QDss oral0.969.8NAFrom Vilade et al. in [18] and [25]
Emtricitabine200 mg QDss oral0.96132[18, 23, 26]
Emtricitabine200 mg QDss oral0.969.71.4From Stek et al. in [18] and [26]
Lamivudine300 mg QDss oral0.6512.7NAFrom Benaboud et al. in [18] and [26]
Metformin500 mg BID0.999.81.6From Eyal et al. in [18] and [26]
Metformin500 mg BID0.999.81.6From Eyal et al. in [18] and [26]
Metformin500 mg BID0.999.81.6From Eyal et al. in [18] and [26]
Metformin500 mg BID0.999.8NAFrom Liao et al. in [18] and [26]
Metformin1,000 mg BID0.999.9NAFrom Liao et al. in [18] and [26]
Cefazolin500 mg IV0.11110NA[19]
Cefuroxime750 mg IV0.6768NA[19]
Cefuroxime750 mg IV0.6768NA[19]
Cefradine500 mg IV0.8038.9NA[19]
Cefradine500 mg oral0.8031.911.8[19]
OC75 mg oral0.973,507**397*[20, 21]
OC75 mg oral0.973,507**397*[20, 21]
OC75 mg oral0.973,507**397*[20, 21]
Amoxicillin500 mg oral0.8020.4***NA[20]
Amoxicillin500 mg oral0.8020.4***NA[20]
Tenofovir300 mg oral0.933.20.33[22, 23, 26]
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* Cmax: ng/mL. ** AUC: ng·hr/mL. *** AUC: μg·hr/mL. **** A middle value between 0.09–0.33. BID: twice daily; fup: fraction unbound protein in plasma; OC: oseltamivir carboxylate; QD: once daily; ss: steady state