Table Info

Table 3.

Updated reaction protocols in microwave-assisted SPPS

Strategy	Reagents and conditions	Ref.
Boc	Solvent: DMF Deprotection: 100% TFA Coupling: HOBt, DIC, and DIPEA or HBTU and DIPEA (for Boc-Asn)	[177]
Fmoc	Solvent: DMF Deprotection: 10% (w/v) piperazine or 20% (v/v) piperidine Coupling: Oxyma pure and DIC	[178, 179]
Fmoc	Solvent: DMF Deprotection: 10% (w/v) piperazine or 20% (v/v) piperidine Coupling: HOBt and DIC or HBTU (or HATU) and DIPEA	[171, 180–183]
Fmoc	Solvent: NMP Deprotection: 10% (w/v) piperazine or 20% (v/v) piperidine Coupling: HBTU (or HATU) and DIPEA	[184]

Ref.: reference; DMF: dimethylformammide; TFA: trifuoloacetic acid; HOBt: hydroxybenzotriazole; DIC: N,N-Diisopropylcarbodiimide; DIPEA: N,N-Diisopropynethylamine; HBTU: 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; NMP: N-Methyl-2-pyrrolidone; HATU: 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate

Declaration

Author contributions

MGC, MC, SS, and KK: Conceptualization, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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