Table Info

Table 2.

Main proteases with their cleavage site and proteolytic mechanism

Proteases	EC	Proteolytic mechanism	Cleavage site
Asn lyases^*	4.3.2	Elimination reaction	Asn-Ala bond
Aspartic peptidases	3.4.23	Acid-base	Cys
Cys peptidases	3.4.22	Catalytic	C-terminal Asn
Glutamate peptidases^*	3.4.23	Hydrolysis	NAA-Glu
Metallopeptidades	3.4.24	Catalytic	Metal-binding residues (i.e. His, Glu, Asp)
Serine peptidases	3.4.21	Acyl-enzyme intermediate	Aromatic amino acids (i.e. Phe-Thr, Tyr-Ser)
Threonine peptidases	3.4.25	N-terminus hydrolysis	N-terminal Met

^* At present not found in mammals (isolated from fungal and bacterial sources). EC: enzymatic class; NAA: N-acetyl aspartate; Asn: asparagine; Ala: alanine; Cys: cysteine; Glu: glutamic acid; His: histidine; Asp: aspartic acid; Phe: phenylalanine; Thr: threonine; Tyr: tyrosine

Declaration

Author contributions

MGC, MC, SS, and KK: Conceptualization, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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