Table Info

Table 1.

Studies utilizing unmodified EVs on PD models

Therapeutic cargo	EV source	Experiment type	Ref.
Natural EV-cargo	SHEDs	In vitro	[74]
Natural EV-cargo	SHEDs	In vivo	[75]
Natural EV-cargo	hUC-MSCs	In vitro and in vivo	[71]
Natural EV-cargo but rich in miRNA-106b	hUC-MSCs	In vitro and in vivo	[70]
Natural EV-cargo but rich in Wnt5	BM-MSCs and BM-MSC-derived DA neuron	In vivo	[77]
Natural EV-cargo	BM-MSCs	In vivo	[79]
Natural EV-cargo but rich in Wnt5	BM-MSCs and BM-MSC-derived DA neuron	In vivo	[78]
Natural EV-cargo	hUC-MSCs	In vitro and in vivo	[76]

Declarations

Acknowledgments

The authors acknowledge Servier Medical Art (https://smart.servier.com) and BioIcons (https://bioicons.com) for providing the icons used for the images. Icons were developed by Servier and DBCLS and licensed under Creative Commons Attribution 3.0 Unported License and Creative Commons Attribution 4.0 International License, respectively.

Author contributions

MRT and ALA equally contributed to: Conceptualization, Writing—original draft, Visualization. VRdC and JRDP: Writing—original draft. RPA: Supervision, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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