From:  Assessment of possible interactions between Citrus aurantifolia leaf alkaloid-rich compounds and relevant protein targets in scopolamine-induced amnesic rats

 Molecular binding affinity of the major constituents of lime leaf alkaloid-rich extract to major memory and cognitive functions linked protein targets.

S/NLigandsTarget protein binding affinity (kcal.mol–1)
Acetylcholinesterase
(P22303)		Adenosine deaminase
(P00813)		Monoamine oxidase
(P21397)
1.Pyrazine trimethyl–5.443–5.360–5.971
2.Tyramine–6.233–6.709–6.832
3.6-Methylnicotinic acid–5.906–5.456–5.989
4.Phenol 4-[2-(methylamino) ethyl]–5.956–5.888–5.976
5.Octopamine–5.571–5.832–6.006
6.Hordenine–5.415–4.910–5.293
7.Quinoline 4-methoxy-–7.230–6.401–6.386
8.Pyridine 3-(1-methyl-2-pyrrolidinyl)-(S)–4.770–5.009–4.473
9.Synephrine–6.111–5.265–5.034
10.2-Norbornanamine N-ethyl-3-phenyl–6.100–6.485–5.319
11.Citracridone I–7.101–7.620–7.406
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