Exploration of Neuroscience

Table 3. Target prediction and network analysis.

Ligand	Target key	Target name	Description	P-value	MaxTC
Pyrazine trimethyl	TGT_ZYMMO	tgt	Queuine tRNA-ribosyltransferase	1.217e-09	0.32
Tyramine	H9TVJ1_CHISP		TyR1	3.027e-111	1.00
	TAAR5_HUMAN	TAAR5	Trace amine-associated receptor 5	1.414e-62	0.50
	SYYC_HUMAN	YARS1	Tyrosine-tRNA ligase, cytoplasmic	2.048e-26	0.32
	HMGB1_HUMAN	HMGB1	High mobility group protein B1	3.081e-26	0.32
6-Methylnicotinic acid	P4HA1_HUMAN	P4HA1	Prolyl 4-hydroxylase subunit alpha-1	1.051e-102	0.62
	HCAR3_HUMAN	HCAR3	Hydroxycarboxylic acid receptor 3	1.943e-98	0.57
	P4HTM_HUMAN	P4HTM	Transmembrane prolyl 4-hydroxylase	1.225e-65	0.62
Phenol 4-[2-(methylamino) ethyl	ERR3_HUMAN	ESRRG	Estrogen-related receptor gamma	1.83e-30	0.47
Octopamine	5HT3A_HUMAN	HTR3A	5-hydroxytryptamine receptor 3A	0.05302	1.00
Hordenine	TOP2B_HUMAN	TOP2B	DNA topoisomerase 2-beta	4.648e-30	0.31
Quinoline 4-methoxy-	S22A2_HUMAN	SLC22A2	Solute carrier family 22 member 2	1.449e-10	0.64
Pyridine 3-(1-methyl-2-pyrrolidinyl)-(S)	ACHB2_HUMAN	CHRNB2	Neuronal acetylcholine receptor subunit beta-2	2.682e-43	1.00
Synephrine	NMUR2_HUMAN	NMUR2	Neuromedin-U receptor 2	3.937e-30	1.00
Synephrine	ADRB2_HUMAN	ADRB2	Beta-2 adrenergic receptor	1.371e-27	0.63
2-Norbornanamine N-ethyl-3-phenyl	ADRB2_HUMAN	ADRB2	Beta-2 adrenergic receptor	1.371e-27	0.63
Citracridone I	DCOR_HUMAN	ODC1	Ornithine decarboxylase	7.101e-61	0.44
Citracridone I	CATL2_HUMAN	CTSV	Cathepsin L2	2.22e-16	0.48

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Supplementary materials

The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/1006153_sup_1.pdf.

Declarations

Acknowledgments

The authors gratefully acknowledge the contribution of Dr Ajayi Babajide towards the purchase of scopolamine hydrobromide trihydrate.

Author contributions

OHO: Conceptualization, Project administration, Formal analysis, Writing—original draft. AAA: Methodology, Formal analysis, Investigation. VOO: Formal analysis, Investigation, Data curation. OPIO: Writing—original draft, Data curation. KAO: Formal analysis, Investigation, Validation. CDF: Data curation, Formal analysis, Methodology. AOA: Formal analysis, Data curation, Validation. OI: Conceptualization, Supervision. All authors reviewed, edited, and approved the final manuscript.

Conflicts of interest

The authors declare that they do not have any conflicts of interest.

Ethical approval

All international, national, and/or institutional guidelines for the care and the use of laboratory animals were strictly followed. The experimental methods were approved by the Research Ethics Committee for animal experimentation of the Faculty of Science, (FUOYE) with ethical approval number, FUOYEFSC 201122 – REC2023/013.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Datasets are available on request.

Funding

This research did not receive any funds, grants, or support from any organisation.

Copyright

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Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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