The table summarizes the three main traditional approaches to cognitive rehabilitation following traumatic brain injury.
Declarations
Acknowledgments
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References
Liu J, Xu A, Zhao Z, Fang D, Lv W, Li Y, et al. The Burden of Traumatic Brain Injury, Its Causes, and Future Trend Predictions in 204 Countries and Territories (1990–2021): Results from the Global Burden of Disease Study 2021.Neuroepidemiology. 2025;60:1–15. [DOI] [PubMed]
Mavroudis I, Ciobica A, Bejenariu AC, Dobrin RP, Apostu M, Dobrin I, et al. Cognitive Impairment following Mild Traumatic Brain Injury (mTBI): A Review.Medicina. 2024;60:380. [DOI] [PubMed] [PMC]
Kohler MJ, Hendrickx MD, Powell-Jones A, Bryan-Hancock C. A Systematic Review of Cognitive Functioning After Traumatic Brain Injury in Individuals Aged 10–30 Years.Cogn Behav Neurol. 2020;33:233–52. [DOI] [PubMed]
Bryant AM, Rose NB, Temkin NR, Barber JK, Manley GT, McCrea MA, et al. Profiles of Cognitive Functioning at 6 Months After Traumatic Brain Injury Among Patients in Level I Trauma Centers.JAMA Netw Open. 2023;6:e2349118. [DOI] [PubMed] [PMC]
Arciniegas DB, Held K, Wagner P. Cognitive impairment following traumatic brain injury.Curr Treat Options Neurol. 2002;4:43–57. [DOI] [PubMed]
Miotto EC, Cinalli FZ, Serrao VT, Benute GG, Lucia MC, Scaff M. Cognitive deficits in patients with mild to moderate traumatic brain injury.Arq NeuroPsiquiatr. 2010;68:862–8. [DOI] [PubMed]
Mathias JL, Wheaton P. Changes in attention and information-processing speed following severe traumatic brain injury: A meta-analytic review.Neuropsychology. 2007;21:212–23. [DOI] [PubMed]
Dymowski AR, Owens JA, Ponsford JL, Willmott C. Speed of processing and strategic control of attention after traumatic brain injury.J Clin Exp Neuropsychol. 2015;37:1024–35. [DOI] [PubMed]
Rao V, Lyketsos C. Neuropsychiatric Sequelae of Traumatic Brain Injury.Psychosomatics. 2000;41:95–103. [DOI] [PubMed]
Rao V, Lyketsos CG. Psychiatric aspects of traumatic brain injury.Psychiatr Clin North Am. 2002;25:43–69. [PubMed]
Osborn AJ, Mathias JL, Fairweather-Schmidt AK. Prevalence of anxiety following adult traumatic brain injury: A meta-analysis comparing measures, samples and postinjury intervals.Neuropsychology. 2016;30:247–61. [DOI] [PubMed]
Scholten AC, Haagsma JA, Cnossen MC, Olff M, van Beeck EF, Polinder S. Prevalence of and Risk Factors for Anxiety and Depressive Disorders after Traumatic Brain Injury: A Systematic Review.J Neurotrauma. 2016;33:1969–94. [DOI] [PubMed]
Johnson VE, Stewart W, Smith DH. Axonal pathology in traumatic brain injury.Exp Neurol. 2013;246:35–43. [DOI] [PubMed] [PMC]
Feiger JA, Snyder RL, Walsh MJ, Cissne M, Cwiek A, Al-Momani SI, et al. The Role of Neuroinflammation in Neuropsychiatric Disorders Following Traumatic Brain Injury: A Systematic Review.J Head Trauma Rehabil. 2022;37:E370–82. [DOI] [PubMed]
Zhao Q, Li H, Li H, Xie F, Zhang J. Research progress of neuroinflammation-related cells in traumatic brain injury: A review.Medicine. 2023;102:e34009. [DOI] [PubMed] [PMC]
Bonnelle V, Ham TE, Leech R, Kinnunen KM, Mehta MA, Greenwood RJ, et al. Salience network integrity predicts default mode network function after traumatic brain injury.Proc Natl Acad Sci. 2012;109:4690–5. [DOI] [PubMed] [PMC]
Sours C, Zhuo J, Janowich J, Aarabi B, Shanmuganathan K, Gullapalli RP. Default mode network interference in mild traumatic brain injury—A pilot resting state study.Brain Res. 2013;1537:201–15. [DOI] [PubMed] [PMC]
Cernich AN, Kurtz SM, Mordecai KL, Ryan PB. Cognitive Rehabilitation in Traumatic Brain Injury.Curr Treat Options Neurol. 2010;12:412–23. [DOI] [PubMed]
Cicerone KD, Goldin Y, Ganci K, Rosenbaum A, Wethe JV, Langenbahn DM, et al. Evidence-Based Cognitive Rehabilitation: Systematic Review of the Literature From 2009 Through 2014.Arch Phys Med Rehabil. 2019;100:1515–33. [DOI] [PubMed]
Carney N, Chesnut RM, Maynard H, Mann NC, Patterson P, Helfand M. Effect of Cognitive Rehabilitation on Outcomes for Persons with Traumatic Brain Injury: A Systematic Review.J Head Trauma Rehabil. 1999;14:277–307. [DOI] [PubMed]
Walker KR, Tesco G. Molecular mechanisms of cognitive dysfunction following traumatic brain injury.Front Aging Neurosci. 2013;5:29. [DOI] [PubMed] [PMC]
Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Dhaliwal AS, Dubova I, et al. Brain Injury–Mediated Neuroinflammatory Response and Alzheimer’s Disease.Neuroscientist. 2019;26:134–55. [DOI] [PubMed] [PMC]
Calderone A, Latella D, Cardile D, Gangemi A, Corallo F, Rifici C, et al. The Role of Neuroinflammation in Shaping Neuroplasticity and Recovery Outcomes Following Traumatic Brain Injury: A Systematic Review.Int J Mol Sci. 2024;25:11708. [DOI] [PubMed] [PMC]
Li N, Lu W, Tang L, Zhu L, Deng W, Liu H, et al. Microglia in Post‐Traumatic Brain Injury (TBI) Cognitive Impairment: From Pathological Changes to Therapeutic Approaches.CNS Neurosci Ther. 2025;31:e70568. [DOI] [PubMed] [PMC]
Krukowski K, Nolan A, Becker M, Picard K, Vernoux N, Frias ES, et al. Novel microglia-mediated mechanisms underlying synaptic loss and cognitive impairment after traumatic brain injury.Brain Behav Immun. 2021;98:122–35. [DOI] [PubMed] [PMC]
Wang J, Zhang B, Li L, Tang X, Zeng J, Song Y, et al. Repetitive traumatic brain injury–induced complement C1-related inflammation impairs long-term hippocampal neurogenesis.Neural Regen Res. 2024;20:821–35. [DOI] [PubMed] [PMC]
Zhang Z, Ishrat S, O'Bryan M, Klein B, Saraswati M, Robertson C, et al. Pediatric Traumatic Brain Injury Causes Long-Term Deficits in Adult Hippocampal Neurogenesis and Cognition.J Neurotrauma. 2020;37:1656–67. [DOI] [PubMed]
Gennarelli TA. Mechanisms of brain injury.J Emerg Med. 1993;11:5–11. [PubMed]
Thapa K, Khan H, Singh TG, Kaur A. Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets.J Mol Neurosci. 2021;71:1725–42. [DOI] [PubMed]
Li F, Lu L, Shang S, Hu L, Chen H, Wang P, et al. Disrupted functional network connectivity predicts cognitive impairment after acute mild traumatic brain injury.CNS Neurosci Ther. 2020;26:1083–91. [DOI] [PubMed] [PMC]
Wang Y, Zhou Y, Zhang X, Wang K, Chen X, Cheng H. Orienting network impairment of attention in patients with mild traumatic brain injury.Behav Brain Res. 2023;437:114133. [DOI] [PubMed]
Wolf JA, Koch PF. Disruption of Network Synchrony and Cognitive Dysfunction After Traumatic Brain Injury.Front Syst Neurosci. 2016;10:43. [DOI] [PubMed] [PMC]
Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR. Diffuse axonal injury in head injury: Definition, diagnosis and grading.Histopathology. 2011;15:49–59. [DOI] [PubMed]
Inglese M, Makani S, Johnson G, Cohen BA, Silver JA, Gonen O, et al. Diffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study.J Neurosurg. 2005;103:298–303. [DOI] [PubMed]
Siedler DG, Chuah MI, Kirkcaldie MT, Vickers JC, King AE. Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments.Front Cell Neurosci. 2014;8:429. [DOI] [PubMed] [PMC]
Khatri N, Thakur M, Pareek V, Kumar S, Sharma S, Datusalia AK. Oxidative Stress: Major Threat in Traumatic Brain Injury.CNS Neurol Disord Drug Targets. 2018;17:689–95. [DOI] [PubMed]
Cornelius C, Crupi R, Calabrese V, Graziano A, Milone P, Pennisi G, et al. Traumatic Brain Injury: Oxidative Stress and Neuroprotection.Antioxid Redox Signal. 2013;19:836–53. [DOI] [PubMed]
Hakiminia B, Alikiaii B, Khorvash F, Mousavi S. Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities.Fundam Clin Pharmacol. 2022;36:612–62. [DOI] [PubMed]
Corrigan F, Mander KA, Leonard AV, Vink R. Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation.J Neuroinflammation. 2016;13:264. [DOI] [PubMed] [PMC]
Ng SY, Lee AYW. Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets.Front Cell Neurosci. 2019;13:528. [DOI] [PubMed] [PMC]
Collins-Praino LE, Corrigan F. Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury?Brain Behav Immun. 2017;60:369–82. [DOI] [PubMed]
Cherry JD, Tripodis Y, Alvarez VE, Huber B, Kiernan PT, Daneshvar DH, et al. Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy.Acta Neuropathol Commun. 2016;4:112. [DOI] [PubMed] [PMC]
Hiskens MI. Targets of Neuroprotection and Review of Pharmacological Interventions in Traumatic Brain Injury.J Pharmacol Exp Ther. 2022;382:149–66. [DOI] [PubMed]
Lin M, Lu Q, Yu S, Lin W. Best Evidence Summary for the Improvement and Management of Disorders of Consciousness in Patients With Severe Brain Injury.Brain Behav. 2025;15:e70260. [DOI] [PubMed] [PMC]
Xiong Y, Mahmood A, Chopp M. Animal models of traumatic brain injury.Nat Rev Neurosci. 2013;14:128–42. [DOI] [PubMed] [PMC]
Wu YH, Rosset S, Lee TR, Dragunow M, Park T, Shim V. In Vitro Models of Traumatic Brain Injury: A Systematic Review.J Neurotrauma. 2021;38:2336–72. [DOI] [PubMed]
Kumaria A. In Vitro Models as a Platform to Investigate Traumatic Brain Injury.Altern Lab Anim. 2017;45:201–11. [DOI] [PubMed]
Nizamutdinov D, Shapiro LA. Overview of Traumatic Brain Injury: An Immunological Context.Brain Sci. 2017;7:11. [DOI] [PubMed] [PMC]
Wofford KL, Loane DJ, Cullen DK. Acute drivers of neuroinflammation in traumatic brain injury.Neural Regen Res. 2019;14:1481–9. [DOI] [PubMed] [PMC]
Münz F, Hoffmann A, Gröger M, Sharon O, Scheer M, Kress S, et al. Pre-Clinical Models of Traumatic Brain Injury—A Narrative Review Towards “Animal Neuro-ICUs”.Biomedicines. 2026;14:688. [DOI] [PubMed] [PMC]
Hamilton KA, Santhakumar V. Current ex vivo and in vitro approaches to uncovering mechanisms of neurological dysfunction after traumatic brain injury.Curr Opin Biomed Eng. 2020;14:18–24. [DOI] [PubMed] [PMC]
Zhang J, Yang H, Wu J, Zhang D, Wang Y, Zhai J. Recent progresses in novel in vitro models of primary neurons: A biomaterial perspective.Front Bioeng Biotechnol. 2022;10:953031. [DOI] [PubMed] [PMC]
Jgamadze D, Johnson VE, Wolf JA, Cullen DK, Song H, Ming GL, et al. Modeling traumatic brain injury with human brain organoids.Curr Opin Biomed Eng. 2020;14:52–8. [DOI] [PubMed] [PMC]
Jena S, Uzoechi S, Badeaux C, Campbell CJ, Egido-Betancourt H, Madi H, et al. Engineering Brain Injury In Vitro: Human iPSC-Based Organoids in Microfluidic Systems.Appl Sci. 2026;16:2309. [DOI] [PubMed] [PMC]
Palacios EM, Sala-Llonch R, Junque C, Roig T, Tormos JM, Bargallo N, et al. Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury.JAMA Neurol. 2013;70:845–51. [DOI] [PubMed]
Sharp DJ, Beckmann CF, Greenwood R, Kinnunen KM, Bonnelle V, De Boissezon X, et al. Default mode network functional and structural connectivity after traumatic brain injury.Brain. 2011;134:2233–47. [DOI] [PubMed]
Azouvi P, Vallat-Azouvi C, Belmont A. Cognitive deficits after traumatic coma.Prog Brain Res. 2009;177:89–110. [DOI] [PubMed]
Johnson LW, Hall KD. A Scoping Review of Cognitive Assessment in Adults With Acute Traumatic Brain Injury.Am J Speech-Lang Pathol. 2022;31:739–56. [DOI] [PubMed]
McInnes K, Friesen CL, MacKenzie DE, Westwood DA, Boe SG. Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review.PLoS ONE. 2017;12:e0174847. [DOI] [PubMed] [PMC]
Rabinowitz AR, Levin HS. Cognitive Sequelae of Traumatic Brain Injury.Psychiatr Clin North Am. 2014;37:1–11. [DOI] [PubMed] [PMC]
Dikmen S, McLean A Jr, Temkin NR, Wyler AR. Neuropsychologic outcome at one-month postinjury.Arch Phys Med Rehabil. 1986;67:507–13. [PubMed]
Andelic N, Howe EI, Hellstrøm T, Sanchez MF, Lu J, Løvstad M, et al. Disability and quality of life 20 years after traumatic brain injury.Brain Behav. 2018;8:e01018. [DOI] [PubMed] [PMC]
Slovarp L, Azuma T, Lapointe L. The effect of traumatic brain injury on sustained attention and working memory.Brain Inj. 2011;26:48–57. [DOI] [PubMed]
Roberts RE, Anderson EJ, Husain M. White Matter Microstructure and Cognitive Function.Neuroscientist. 2011;19:8–15. [DOI] [PubMed] [PMC]
Kerchner GA, Racine CA, Hale S, Wilheim R, Laluz V, Miller BL, et al. Cognitive Processing Speed in Older Adults: Relationship with White Matter Integrity.PLoS ONE. 2012;7:e50425. [DOI] [PubMed] [PMC]
Ponsford J, Willmott C, Rothwell A, Cameron P, Ayton G, Nelms R, et al. Cognitive and Behavioral Outcome Following Mild Traumatic Head Injury in Children.J Head Trauma Rehabil. 1999;14:360–72. [DOI] [PubMed]
Levin HS, Grafman J, eitors. Cerebral Reorganization of Function After Brain Damage. Oxford: Oxford University Press; 2000. [DOI]
Smith DH, Meaney DF, Shull WH. Diffuse Axonal Injury in Head Trauma.J Head Trauma Rehabil. 2003;18:307–16. [DOI] [PubMed]
McDonald BC, Flashman LA, Saykin AJ. Executive dysfunction following traumatic brain injury: neural substrates and treatment strategies.NeuroRehabilitation. 2002;17:333–44. [PubMed]
Ownsworth T, Fleming J. The Relative Importance of Metacognitive Skills, Emotional Status, and Executive Function in Psychosocial Adjustment Following Acquired Brain Injury.J Head Trauma Rehabil. 2005;20:315–32. [DOI] [PubMed]
Fish J, Evans JJ, Nimmo M, Martin E, Kersel D, Bateman A, et al. Rehabilitation of executive dysfunction following brain injury: “Content-free” cueing improves everyday prospective memory performance.Neuropsychologia. 2007;45:1318–30. [DOI] [PubMed]
Howlett JR, Nelson LD, Stein MB. Mental Health Consequences of Traumatic Brain Injury.Biol Psychiatry. 2022;91:413–20. [DOI] [PubMed] [PMC]
Jahan AB, Tanev K. Neurobiological Mechanisms Of Depression Following Traumatic Brain Injury.Brain Inj. 2022;37:24–33. [DOI] [PubMed]
Bryant BR, Richey LN, Jahed S, Heinzerling A, Stevens DA, Pace BD, et al. Behavioral and Emotional Dyscontrol Following Traumatic Brain Injury: A Systematic Review of Neuroimaging and Electrophysiological Correlates.J Acad Consult Liaison Psychiatry. 2022;63:579–98. [DOI] [PubMed] [PMC]
Gruenbaum BF, Zlotnik A, Fleidervish I, Frenkel A, Boyko M. Glutamate Neurotoxicity and Destruction of the Blood–Brain Barrier: Key Pathways for the Development of Neuropsychiatric Consequences of TBI and Their Potential Treatment Strategies.Int J Mol Sci. 2022;23:9628. [DOI] [PubMed] [PMC]
van der Horn HJ, Mangina NR, Rakers SE, Kok JG, Timmerman ME, Leemans A, et al. White matter microstructure of the neural emotion regulation circuitry in mild traumatic brain injury.Eur J Neurosci. 2021;53:3463–75. [DOI] [PubMed] [PMC]
Medeiros GC, Twose C, Weller A, Dougherty JW 3rd, Goes FS, Sair HI, et al. Neuroimaging Correlates of Depression after Traumatic Brain Injury: A Systematic Review.J Neurotrauma. 2022;39:755–72. [DOI] [PubMed]
Menon V. Large-scale brain networks and psychopathology: a unifying triple network model.Trends Cogn Sci. 2011;15:483–506. [DOI] [PubMed]
Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, et al. Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control.J Neurosci. 2007;27:2349–56. [DOI] [PubMed] [PMC]
Uddin LQ. Salience processing and insular cortical function and dysfunction.Nat Rev Neurosci. 2014;16:55–61. [DOI] [PubMed]
Ramage AE, Ray KL, Franz HM, Tate DF, Lewis JD, Robin DA. Cingulo-Opercular and Frontoparietal Network Control of Effort and Fatigue in Mild Traumatic Brain Injury.Front Hum Neurosci. 2022;15:788091. [DOI] [PubMed] [PMC]
Lan YL, Li S, Lou JC, Ma XC, Zhang B. The potential roles of dopamine in traumatic brain injury: a preclinical and clinical update.Am J Transl Res. 2019;11:2616–31. [PubMed] [PMC]
Valko PO, Gavrilov YV, Yamamoto M, Noaín D, Reddy H, Haybaeck J, et al. Damage to Arousal-Promoting Brainstem Neurons with Traumatic Brain Injury.Sleep. 2016;39:1249–52. [DOI] [PubMed] [PMC]
Dehbozorgi M, Maghsoudi MR, Rajai S, Mohammadi I, Nejad AR, Rafiei MA, et al. Depression after traumatic brain injury: A systematic review and Meta-analysis.Am J Emerg Med. 2024;86:21–9. [DOI] [PubMed]
Choi Y, Kim EY, Sun J, Kim HK, Lee YS, Oh BM, et al. Incidence of Depression after Traumatic Brain Injury: A Nationwide Longitudinal Study of 2.2 Million Adults.J Neurotrauma. 2022;39:390–7. [DOI] [PubMed] [PMC]
Bodnar CN, Morganti JM, Bachstetter AD. Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism.Neural Regen Res. 2018;13:1693–704. [DOI] [PubMed] [PMC]
Dehbozorgi M, Maghsoudi MR, Mohammadi I, Firouzabadi SR, Mohammaditabar M, Oraee S, et al. Incidence of anxiety after traumatic brain injury: a systematic review and meta-analysis.BMC Neurol. 2024;24:293. [DOI] [PubMed] [PMC]
Hoffman AN, Taylor AN. Stress reactivity after traumatic brain injury: implications for comorbid post-traumatic stress disorder.Behav Pharmacol. 2019;30:115–21. [DOI] [PubMed] [PMC]
Weis CN, Webb EK, deRoon-Cassini TA, Larson CL. Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders.Biol Psychiatry. 2022;91:470–7. [DOI] [PubMed] [PMC]
Torregrossa W, Raciti L, Rifici C, Rizzo G, Raciti G, Casella C, et al. Behavioral and Psychiatric Symptoms in Patients with Severe Traumatic Brain Injury: A Comprehensive Overview.Biomedicines. 2023;11:1449. [DOI] [PubMed] [PMC]
Leśniak MM, Iwański S, Szutkowska-Hoser J, Seniów J. Comprehensive cognitive training improves attention and memory in patients with severe or moderate traumatic brain injury.Appl Neuropsychol Adult. 2019;27:570–9. [DOI] [PubMed]
Rodríguez-Rajo P, Leno Colorado D, Enseñat-Cantallops A, García-Molina A. Rehabilitation of social cognition impairment after traumatic brain injury: a systematic review.Neurol (Engl Ed). 2022;37:767–80. [DOI] [PubMed]
Alashram AR. Compensatory cognitive training for people with traumatic brain injury: A systematic review of randomized controlled trial.Appl Neuropsychol Adult. 2024;32:1794–802. [DOI] [PubMed]
Fleming J, Ownsworth T, Doig E, Hogan C, Hamilton C, Swan S, et al. Efficacy of Prospective Memory Rehabilitation Plus Metacognitive Skills Training for Adults With Traumatic Brain Injury: A Randomized Controlled Trial.Neurorehabilit Neural Repair. 2022;36:487–99. [DOI] [PubMed]
Maggio MG, De Luca R, Molonia F, Porcari B, Destro M, Casella C, et al. Cognitive rehabilitation in patients with traumatic brain injury: A narrative review on the emerging use of virtual reality.J Clin Neurosci. 2019;61:1–4. [DOI] [PubMed]
Robertson IH, Murre JM. Rehabilitation of brain damage: Brain plasticity and principles of guided recovery.Psychol Bull. 1999;125:544–75. [DOI] [PubMed]
Barman A, Chatterjee A, Bhide R. Cognitive Impairment and Rehabilitation Strategies After Traumatic Brain Injury.Indian J Psychol Med. 2016;38:172–81. [DOI] [PubMed] [PMC]
Zemsky C, Gillen G. Compensatory Strategies to Improve Functional Cognition Post-Stroke: A Review for Caregiver Empowerment and Burden Reduction.Brain Sci. 2025;15:1297. [DOI] [PubMed] [PMC]
White SM, Seckinger S, Doyle M, Strauss DL. Compensatory strategies for people with traumatic brain injury.NeuroRehabilitation. 1997;9:205–12. [DOI] [PubMed]
Kinsella G, Murtagh D, Landry A, Homfray K, Hammond M, O'Beirne L, et al. Everyday memory following traumatic brain injury.Brain Inj. 2009;10:499–507. [DOI] [PubMed]
Doig EJ, Fleming J, Ownsworth T. Evaluation of an occupation-based metacognitive intervention targeting awareness, executive function and goal-related outcomes after traumatic brain injury using single-case experimental design methodology.Neuropsychol Rehabil. 2020;31:1527–56. [DOI] [PubMed]
Hallock H, Collins D, Lampit A, Deol K, Fleming J, Valenzuela M. Cognitive Training for Post-Acute Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Front Hum Neurosci. 2016;10:537. [DOI] [PubMed] [PMC]
Séguin M, Lahaie A, Matte-Gagné C, Beauchamp MH. Ready! Set? Let's Train!: Feasibility of an intensive attention training program and its beneficial effect after childhood traumatic brain injury.Ann Phys Rehabil Med. 2018;61:189–96. [DOI] [PubMed]
Yoshida K, Ogawa K, Mototani T, Inagaki Y, Sawamura D, Ikoma K, et al. Flow experience enhances the effectiveness of attentional training: A pilot randomized controlled trial of patients with attention deficits after traumatic brain injury.NeuroRehabilitation. 2018;43:183–93. [DOI] [PubMed]
McDonald BC, Flashman LA, Arciniegas DB, Ferguson RJ, Xing L, Harezlak J, et al. Methylphenidate and Memory and Attention Adaptation Training for Persistent Cognitive Symptoms after Traumatic Brain Injury: A Randomized, Placebo-Controlled Trial.Neuropsychopharmacology. 2016;42:1766–75. [DOI] [PubMed] [PMC]
Chiaravalloti ND, Sandry J, Moore NB, DeLuca J. An RCT to Treat Learning Impairment in Traumatic Brain Injury.Neurorehabilit Neural Repair. 2015;30:539–50. [DOI] [PubMed]
das Nair R, Bradshaw LE, Carpenter H, Clarke S, Day F, Drummond A, et al. A group memory rehabilitation programme for people with traumatic brain injuries: the ReMemBrIn RCT.Health Technol Assess. 2019;23:1–194. [DOI] [PubMed] [PMC]
Dou ZL, Man DW, Ou HN, Zheng JL, Tam SF. Computerized errorless learning-based memory rehabilitation for Chinese patients with brain injury: A preliminary quasi-experimental clinical design study.Brain Inj. 2009;20:219–25. [DOI] [PubMed]
Levine B, Robertson IH, Clare L, Carter G, Hong J, Wilson BA, et al. Rehabilitation of executive functioning: An experimental–clinical validation of Goal Management Training.J Int Neuropsychol Soc. 2000;6:299–312. [DOI] [PubMed]
Waid-Ebbs JK, BCBA-D, Daly J, Wu SS, Berg WK, Bauer RM, et al. Response to Goal Management Training in Veterans with blast-related mild traumatic brain injury.J Rehabil Res Dev. 2014;51:1555–66. [DOI] [PubMed]
Archer KR, Coronado RA, Haislip LR, Abraham CM, Vanston SW, Lazaro AE, et al. Telephone-based goal management training for adults with mild traumatic brain injury: study protocol for a randomized controlled trial.Trials. 2015;16:244. [DOI] [PubMed] [PMC]
Jeffay E, Ponsford J, Harnett A, Janzen S, Patsakos E, Douglas J, et al. INCOG 2.0 Guidelines for Cognitive Rehabilitation Following Traumatic Brain Injury, Part III: Executive Functions.J Head Trauma Rehabil. 2023;38:52–64. [DOI] [PubMed]
Cicerone KD, Langenbahn DM, Braden C, Malec JF, Kalmar K, Fraas M, et al. Evidence-Based Cognitive Rehabilitation: Updated Review of the Literature From 2003 Through 2008.Arch Phys Med Rehabil. 2011;92:519–30. [DOI] [PubMed]
Gao M, Huang L, Yi J, Zhang T, Zhu G, Zhang Q, et al. The Effectiveness of Computerized Cognitive Training in Patients With Poststroke Cognitive Impairment: Systematic Review and Meta-Analysis.J Med Internet Res. 2025;27:e73140. [DOI] [PubMed] [PMC]
Carvalho CM, Poltronieri BC, Reuwsaat K, Reis MEA, Panizzutti R. Digital cognitive training for functionality in mild cognitive impairment: a randomized controlled clinical trial.GeroScience. 2025;47:5111–21. [DOI] [PubMed] [PMC]
Chi K, Chen J, Zhou S, Han Z. The effectiveness of digital cognitive intervention in patients with traumatic brain injury: systematic review and meta-analysis.Front Neurol. 2025;16:1651443. [DOI] [PubMed] [PMC]
Avramovic P, Rietdijk R, Attard M, Kenny B, Power E, Togher L. Cognitive and Behavioral Digital Health Interventions for People with Traumatic Brain Injury and Their Caregivers: A Systematic Review.J Neurotrauma. 2023;40:159–94. [DOI] [PubMed]
Alashram AR. Computerized cognitive rehabilitation for patients with traumatic brain injury: A systematic review of randomized controlled trials.Appl Neuropsychol Adult. 2024;33:578–87. [DOI] [PubMed]
Lakicevic N, Andjelic B, Manojlovic M, Gentile A, Bianco A, Paoli A, et al. Virtual reality and cognitive function rehabilitation after traumatic brain injury: a systematic review.Eur J Transl Myol. 2025;35. [DOI] [PubMed] [PMC]
Manivannan S, Al-Amri M, Postans M, Westacott LJ, Gray W, Zaben M. The Effectiveness of Virtual Reality Interventions for Improvement of Neurocognitive Performance After Traumatic Brain Injury: A Systematic Review.J Head Trauma Rehabil. 2019;34:E52–65. [DOI] [PubMed]
Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018).Clin Neurophysiol. 2020;131:474–528. [DOI] [PubMed]
Miniussi C, Harris JA, Ruzzoli M. Modelling non-invasive brain stimulation in cognitive neuroscience.Neurosci Biobehav Rev. 2013;37:1702–12. [DOI] [PubMed]
Bikson M, Grossman P, Thomas C, Zannou AL, Jiang J, Adnan T, et al. Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016.Brain Stimul. 2016;9:641–61. [DOI] [PubMed] [PMC]
Burton CZ, Garnett EO, Capellari E, Chang SE, Tso IF, Hampstead BM, et al. Combined Cognitive Training and Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: A Systematic Review and Meta-analysis.Biol Psychiatry: Cogn Neurosci Neuroimaging. 2023;8:151–61. [DOI] [PubMed] [PMC]
Alashram AR, Padua E, Annino G. Noninvasive brain stimulation for cognitive rehabilitation following traumatic brain injury: A systematic review.Appl Neuropsychol Adult. 2022;30:814–29. [DOI] [PubMed]
Stevens AR, Belli A, Ahmed Z. Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord.Biomedicines. 2024;12:643. [DOI] [PubMed] [PMC]
Wen Z, Li D, Shen M, Chen G. Therapeutic Potentials of Synapses after Traumatic Brain Injury: A Comprehensive Review.Neural Plast. 2017;2017:4296075. [DOI] [PubMed] [PMC]
Aqel S, Al-Thani N, Haider MZ, Abdelhady S, Al Thani AA, Kobeissy F, et al. Biomaterials in Traumatic Brain Injury: Perspectives and Challenges.Biology. 2023;13:21. [DOI] [PubMed] [PMC]
Zhu S, Liu X, Lu X, Liao Q, Luo H, Tian Y, et al. Biomaterials and tissue engineering in traumatic brain injury: novel perspectives on promoting neural regeneration.Neural Regen Res. 2023;19:2157–74. [DOI] [PubMed] [PMC]
Hu H, Chen X, Zhao K, Zheng W, Gao C. Recent Advances in Biomaterials‐Based Therapies for Alleviation and Regeneration of Traumatic Brain Injury.Macromol Biosci. 2023;23:e2200577. [DOI] [PubMed]
Giesler LP, Mychasiuk R, Shultz SR, McDonald SJ. BDNF: New Views of an Old Player in Traumatic Brain Injury.Neuroscientist. 2023;30:560–73. [DOI] [PubMed] [PMC]
Sims SK, Wilken-Resman B, Smith CJ, Mitchell A, McGonegal L, Sims-Robinson C. Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research.Neural Plast. 2022;2022:3889300. [DOI] [PubMed] [PMC]
Yarahmadi A, Dorri Giv M, Hosseininejad R, Rezaie A, Mohammadi N, Afkhami H, et al. Mesenchymal stem cells and their extracellular vesicle therapy for neurological disorders: traumatic brain injury and beyond.Front Neurol. 2025;16:1472679. [DOI] [PubMed] [PMC]
Das M, Mayilsamy K, Mohapatra SS, Mohapatra S. Mesenchymal stem cell therapy for the treatment of traumatic brain injury: progress and prospects.Rev Neurosci. 2019;30:839–55. [DOI] [PubMed]
Muhammad SA, Abbas AY, Imam MU, Saidu Y, Bilbis LS. Efficacy of stem cell secretome in the treatment of traumatic brain injury: A systematic review and meta-analysis of preclinical studies.Mol Neurobiol. 2022;59:2894–909. [DOI] [PubMed]
Pignataro G, Sacco Fernandez M, Candelli M, Rozzi G, Piccioni A, Forte E, et al. Blood-Based Biomarkers for Traumatic Brain Injury: A New Era in Diagnosis and Prognosis.Int J Mol Sci. 2025;26:12158. [DOI] [PubMed] [PMC]
Huibregtse ME, Bazarian JJ, Shultz SR, Kawata K. The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury.Neurosci Biobehav Rev. 2021;130:433–47. [DOI] [PubMed] [PMC]
Mondello S, Amrein K, Czeiter E, Citerio G, Diaz-Arrastia R, Gao G, et al. Prognostic Value of Blood-Based Protein Biomarkers in Traumatic Brain Injury: A Living Systematic Review and Meta-Analysis.J Neurotrauma. 2025;42:1256–86. [DOI] [PubMed]