Data availability summary across Phases.
| Measure | Phase 1 | Phase 2 | Phase 3 | Phase 4 | Phase 5 |
|---|---|---|---|---|---|
| Questionnaire | Y | - | - | Y | Y |
| Cognitive measures | |||||
| ACE-R | Y | Y (Arm2) | MMSE only | - | Y |
| Cattell | - | Y | MRI version | Y | Y |
| Spot the Word Task | Y | Y (Arm2) | - | Y | Y |
| Reaction Time | Y | - | MRI version | Y (opt) | Y |
| Verbal Memory | Y | - | - | Y (opt) | Y |
| Digit-Symbol Substitution | - | Y (Arm2) | - | Y (opt) | Y |
| Visual Short Term Memory | - | Y | MRI version | - | Y (opt) |
| Motor Learning | - | Y | - | - | Y (opt) |
| Stop-Signal, Go/No-Go | - | - | MEG version | Y | MEG version |
| Physiological measures | |||||
| Blood Pressure | - | Y | Y | - | Y |
| ECG | - | Y | Y | - | Y |
| Height | - | Y | Y | - | Y |
| Weight | - | Y | Y | - | Y |
| Grip Strength | - | - | - | - | Y |
| Motor Learning | - | Y (Arm1) | - | - | Y |
| Hearing/Vision | Y | Y | Y | - | Y |
| MRI | |||||
| T1-weighted structural | - | Y | Y | - | Y |
| Arterial Spin Labelling | - | Y (Arm2) | Y | - | Y |
| Resting State | - | Y | Y | - | Y |
| Sensorimotor Task (active) | - | Y (Arm1) | - | - | Y |
| Movie | - | Y | - | - | Y |
| Field Mapping | - | Y | Y | - | Y |
| T2-weighted SPACE/FLAIR | - | Y (Arm1) | Y | - | Y |
| Diffusion-weighted (main run) | - | Y | - | - | Y |
| Magnetisation transfer-weighted | - | Y | - | - | Y |
| MEG | |||||
| Resting State | - | Y | Y | - | Y |
| Sensorimotor Task (active) | - | Y | - | - | Y |
| Sensorimotor Task (passive) | - | Y | - | - | Y |
| Movie | - | - | - | - | Y |
| Stop-Signal, Go/No-Go | - | - | Y | - | Y |
| Multi-Mismatch Negativity | - | Y (Arm2) | Y | - | Y |
Note that sometimes the test format (online/paper, at-home/in-lab) varied across Phases, and MRI versions differed from main versions of task. Opt = optional.
1 Note that we used the term “stage” in Shafto et al. (2014) rather than “phase”, but these two terms are inter-changeable within Cam-CAN.
We thank the Cam-CAN respondents and their primary care teams in Cambridge for their participation in this study, and colleagues at the MRC Cognition and Brain Sciences Unit MEG and MRI facilities for their assistance. We thank Tom Hartley, Matt Davis, Hugo Spiers, and Claire Lancaster for assistance with some of the tasks.
Cam-CAN co-author includes the following: Project principal personnel: Richard N Henson, Lorraine K Tyler, Kamen A Tsvetanov, Carol Brayne, Edward T Bullmore, Andrew C Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Fiona E Matthews, William D Marslen-Wilson, James B Rowe, Meredith A Shafto, Marta Correia; Research Associates: Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, Anna McCarrey, Abdur Mustafa, Darren Price, David Samu, Jason R Taylor, Matthias Treder, Janna van Belle, Nitin Williams, Daniel J Mitchell, Simon Fisher, Else Eising, Ethan Knights, Adam Attaheri, Dace Apsvalka, Maite Crespo-Garcia; Research Assistants: Lauren Bates, Tina Emery, Sharon Erzinçlioğlu, Andrew Gadie, Sofia Gerbase, Stanimira Georgieva, Claire Hanley, Beth Parkin, David Troy, Ina Demetriou, Will Duckett; Affiliated Personnel: Tibor Auer, Lu Gao, Emma Green, Rafael Henriques; Research Interviewers: Jodie Allen, Gillian Amery, Liana Amunts, Anne Barcroft, Amanda Castle, Cheryl Dias, Jonathan Dowrick, Melissa Fair, Hayley Fisher, Anna Goulding, Adarsh Grewal, Geoff Hale, Andrew Hilton, Frances Johnson, Patricia Johnston, Thea Kavanagh-Williamson, Magdalena Kwasniewska, Alison McMinn, Kim Norman, Jessica Penrose, Fiona Roby, Diane Rowland, John Sargeant, Maggie Squire, Beth Stevens, Aldabra Stoddart, Cheryl Stone, Tracy Thompson, Ozlem Yazlik; and administrative staff: Dan Barnes, Marie Dixon, Jaya Hillman, Joanne Mitchell, Laura Villis.
ID: Data curation, Investigation, Writing—original draft, Writing—review & editing. AA: Data curation, Investigation, Writing—review & editing. RH: Conceptualisation, Methodology, Data curation, Software, Formal analysis, Funding acquisition, Project administration, Resources, Writing—original draft, Writing—review & editing. KAT, KC, JR, NW: Conceptualisation, Methodology, Software, Writing—review & editing. TB, WD, LB: Data curation, Investigation, Writing—review & editing. PR, MMC, DA, MCG, AM, DJM, SEH, Cam-CAN: Writing—review & editing. All authors approved the final version of the manuscript.
The authors declare that they have no competing interests.
The Cam-CAN study was conducted in compliance with the Helsinki Declaration and approved by the Cambridgeshire 2 Research Ethics Committee (reference: 10/H0308/50).
Informed consent to participate in the study was obtained from all participants.
Not applicable.
Data and materials available from: https://cam-can.mrc-cbu.cam.ac.uk/materials/ and https://github.com/InaDemetriou/CamCAN-LongitudinalProtocol.
Cam-CAN was initially supported by the Biotechnology and Biological Sciences Research Council Grant [BB/H008217/1], then received further contributions from the European Union’s Horizon 2020 research and innovation programme (‘LifeBrain’, Grant Agreement No. [732592]). It was subsequently supported by the Medical Research Council (MRC) core Unit grant [SUAG/094 G116768] and Programme grant to R.H. [SUAG/086 G116768]. K.A.T was supported by Fellowship awards from the Alzheimer’s Society (Grant Nr. [6002]) and the Guarantors of Brain [G101149]. J.R. is supported by the Wellcome Trust [220258] and the NIHR Cambridge Biomedical Research Centre [NIHR203312]. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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