Exploration of Neuroscience

Table 2. Phase 5 (Rescan) session content and timing, listed by category.

Session	Measure	Modality	~ Time (mins)
Online
	*Core*
	The Science of Ageing Questionnaire	Questionnaire	20
	The Cattell Task	Cognitive	20
	Spot the Word Task	Cognitive	5
	Reaction Time Task	Cognitive	8
	Digit-Letter Substitution Task	Cognitive	2
	*Extended*
	Visual Short-Term Memory Task	Cognitive	20
	Spatial Memory Task (4MT)	Cognitive	10
	Visual Long-Term Memory Task	Cognitive	15
	Listen-Up Task	Cognitive	10
	Word-Meaning Definitions Task	Cognitive	12
	Predictive Inference Task	Cognitive	15
	Sea Hero Quest	Cognitive	10
MRI session
	Vision	Sensory	2
	Hearing	Sensory	2
	Weight	Physiological	1
	Height	Physiological	1
	Blood Pressure (BP)	Physiological	5
	Pulse (during MRI)	Physiological	MRI duration
	Respiratory Rate (during MRI)	Physiological	MRI duration
	Beat-to-Beat BP (during MRI)	Physiological	MRI duration
	ACE-R	Cognitive	20
	Movie Recall	Cognitive	5
	Sleepiness Scale	Physiological	3
	T1-Weighted Structural	MRI	5
	Arterial Spin Labelling	MRI	8
	fMRI Resting_state	MRI	9
	fMRI Sensorimotor_task	MRI	9
	fMRI Movie	MRI	9
	Field Mapping	MRI	1
	T2-weighted FLAIR	MRI	5
	Diffusion-weighted (main run)	MRI	10
	Diffusion-Weighted (reverse PE)	MRI	1
	Magnetisation Transfer-Weighted	MRI	9
MEG session
	Grip Strength	Physiological	2
	Hearing	Sensory	2
	Motor Learning	Cognitive	10
	Story Memory Task	Cognitive	3
	Movie Recall	Cognitive	5
	Sleepiness Scale	Physiological	3
	Resting State	MEG	10
	Sensorimotor Task (active)	MEG	10
	Sensorimotor Task (passive)	MEG	3
	Movie	MEG	8
	Story Listening	MEG	10
	Stop Signal, Go/No-Go	MEG	10
	Multi-Mismatch Negativity (MMN)	MEG	10

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Footnote

¹ Note that we used the term “stage” in Shafto et al. (2014) rather than “phase”, but these two terms are inter-changeable within Cam-CAN.

Declarations

Acknowledgements

We thank the Cam-CAN respondents and their primary care teams in Cambridge for their participation in this study, and colleagues at the MRC Cognition and Brain Sciences Unit MEG and MRI facilities for their assistance. We thank Tom Hartley, Matt Davis, Hugo Spiers, and Claire Lancaster for assistance with some of the tasks.

Cam-CAN co-author includes the following: Project principal personnel: Richard N Henson, Lorraine K Tyler, Kamen A Tsvetanov, Carol Brayne, Edward T Bullmore, Andrew C Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Fiona E Matthews, William D Marslen-Wilson, James B Rowe, Meredith A Shafto, Marta Correia; Research Associates: Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, Anna McCarrey, Abdur Mustafa, Darren Price, David Samu, Jason R Taylor, Matthias Treder, Janna van Belle, Nitin Williams, Daniel J Mitchell, Simon Fisher, Else Eising, Ethan Knights, Adam Attaheri, Dace Apsvalka, Maite Crespo-Garcia; Research Assistants: Lauren Bates, Tina Emery, Sharon Erzinçlioğlu, Andrew Gadie, Sofia Gerbase, Stanimira Georgieva, Claire Hanley, Beth Parkin, David Troy, Ina Demetriou, Will Duckett; Affiliated Personnel: Tibor Auer, Lu Gao, Emma Green, Rafael Henriques; Research Interviewers: Jodie Allen, Gillian Amery, Liana Amunts, Anne Barcroft, Amanda Castle, Cheryl Dias, Jonathan Dowrick, Melissa Fair, Hayley Fisher, Anna Goulding, Adarsh Grewal, Geoff Hale, Andrew Hilton, Frances Johnson, Patricia Johnston, Thea Kavanagh-Williamson, Magdalena Kwasniewska, Alison McMinn, Kim Norman, Jessica Penrose, Fiona Roby, Diane Rowland, John Sargeant, Maggie Squire, Beth Stevens, Aldabra Stoddart, Cheryl Stone, Tracy Thompson, Ozlem Yazlik; and administrative staff: Dan Barnes, Marie Dixon, Jaya Hillman, Joanne Mitchell, Laura Villis.

Author contributions

ID: Data curation, Investigation, Writing—original draft, Writing—review & editing. AA: Data curation, Investigation, Writing—review & editing. RH: Conceptualisation, Methodology, Data curation, Software, Formal analysis, Funding acquisition, Project administration, Resources, Writing—original draft, Writing—review & editing. KAT, KC, JR, NW: Conceptualisation, Methodology, Software, Writing—review & editing. TB, WD, LB: Data curation, Investigation, Writing—review & editing. PR, MMC, DA, MCG, AM, DJM, SEH, Cam-CAN: Writing—review & editing. All authors approved the final version of the manuscript.

Conflicts of interest

The authors declare that they have no competing interests.

Ethical approval

The Cam-CAN study was conducted in compliance with the Helsinki Declaration and approved by the Cambridgeshire 2 Research Ethics Committee (reference: 10/H0308/50).

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

Data and materials available from: https://cam-can.mrc-cbu.cam.ac.uk/materials/ and https://github.com/InaDemetriou/CamCAN-LongitudinalProtocol.

Funding

Cam-CAN was initially supported by the Biotechnology and Biological Sciences Research Council Grant [BB/H008217/1], then received further contributions from the European Union’s Horizon 2020 research and innovation programme (‘LifeBrain’, Grant Agreement No. [732592]). It was subsequently supported by the Medical Research Council (MRC) core Unit grant [SUAG/094 G116768] and Programme grant to R.H. [SUAG/086 G116768]. K.A.T was supported by Fellowship awards from the Alzheimer’s Society (Grant Nr. [6002]) and the Guarantors of Brain [G101149]. J.R. is supported by the Wellcome Trust [220258] and the NIHR Cambridge Biomedical Research Centre [NIHR203312]. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Copyright

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