From:  Perspectives on the use of flavonoids in glioblastoma treatment by targeting adenosine receptors

 Affinities of a set of flavonoids in radioligand binding assays at A1, A2A, and A3 ARs.

FlavonoidpKi
A1ARA2AARA3AR
vs [3H]-DPCPXvs [3H]-PIAvs [3H]-NECAvs [3H]-CGS21680vs [125I]-AB-MECA
3-methoxyflavone6.04a5.29b
3′,4′-dihydroxyflavonol5.57a6.33b
3,5,6,7,8,3′,4′-heptamethoxyflavone4.80c4.40d
3,5,7,3′,4′-pentamethoxyflavone4.76c4.34d
5,7-dimethoxyflavone5.51a
Apigenin5.52c5.12d
Biochanin A4.46c
Cirsimarin5.49e
Cirsimaritin5.92c5.52d5.76f
Daidzein4.63c
Flavanone< 4.00g4.49c4.30f
Flavone5.16g5.48c5.46d4.77f
Galangin6.05a6.06c6.02d5.50f, 4.37h
Genistein4.67g4.90c> 4.00f
Hexamethylmyricetin> 6.00c4.79f
Hispidulin5.79c5.19d
Kaempferol5.81a, 4.94g6.00b
Morin4.86c4.76d> 4.00f
Naringenin4.53g
Nobiletin5.43c4.67d
Pentamethylmorin4.56c4.33d5.58f
Prunetin> 4.00c
Quercetin5.33g5.61c5.16d
Rhamnetin5.86f
Sakuranetin5.09c4.45d5.47f
Sinensetin6.06c4.94d
Swertisin4.10i
Tangeretin5.35c4.63d
Taxifolin> 5.00c4.47f
Tetramethylkaempferol6.03a5.97c5.47f
Tetramethylscutellarein5.84c4.84d5.35f
Trimethoxyflavone6.29c5.19d5.92f

a Rat whole brain membranes [12]. b Rat striatal membranes [12]. c Rat brain membranes [9, 11, 24]. d Rat striatal membranes [9, 11, 24]. e Rat forebrain membranes [23]. f Human brain A3AR expressed in HEK-293 cells [9, 11]. g Guinea-pig cerebral cortex particulate preparations [21]. h Rat brain A3AR expressed in CHO cells [9, 11]. i Human A1AR expressed in CHO cells [10]. AB-MECA: N6-(4-amino-3-iodobenzyl)adenosine-5′-(N-methyluronamide); AR: adenosine receptor; CGS21680: 2-[[4-(2-carboxyethyl)phenyl]ethylamino]-5′-(N-ethylcarbamoyl)adenosine; DPCPX: 8-cyclopentyl-1,3-dipropylxanthine; NECA: 5′-N-ethylcarboxamidoadenosine; PIA: N6-phenylisopropyladenosine.