Table Info

Table 2.

Self-replicating RNA viruses and examples of clinical trials on infectious diseases

Vaccine candidate	Indication	Status	Reference
Recombinant particles
MV-LASV (V182-001)	LF	Phase I: 52 volunteers, in progress	NCT04055454
VSV-ZEBOV	EVD	Phase III: good vaccine efficacy	[89]
VSV-ZEBOV	EVD	Phase III: good vaccine efficacy	[90]
VSV-ZEBOV	EVD	Approval by the FDA & EMA	[91]
VEE-HIV-Gag (AVX101)	HIV/AIDS	Phase I: two studies terminated	[94]
MV-SARS-CoV-2 S (TMV-083)	COVID-19	Phase I: weak response, terminated	NCT04497298
VSV-SARS-CoV-2 S (V590)	COVID-19	Phase I: weak response, terminated	NCT04469786
VSVΔG-SARS-CoV-2 S (IIBR-100)	COVID-19	Phase I/II: study in progress	NCT04608305
VSVΔG-SARS-CoV-2 S (IIBR-100)	COVID-19	Phase IIb/III: study registered	NCT04990466
Attenuated virus
CYD-TDV	DHF	Vaccine efficacy in several trials	[92]
CYD-TDV (Dengvaxia^®)	DHF	Regulatory approval	[93]
RNA replicons
SARS-CoV-2 S RNA-LNP (COVAC1)	COVID-19	Phase I/II: no results available	ISRCTN17072692

DHF: dengue hemorrhagic fever; EMA: European Medicines Agency; FDA: Food and Drug Administration; LF: Lassa fever

Declarations

Author contributions

The author contributed solely to the work.

Conflicts of interest

The author declares that he has no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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