Tα1 treatment was associated with higher ΔSOFAday07 in patients with sepsis
Model 1
Model 2a
Model 3b
Sample size (n)
288
288
222
Tα1 treatment
0.510 (0.299–0.869)
0.523 (0.301–0.909)
0.336 (0.170–0.663)
Values are ORs (95% CIs) unless stated otherwise. aAdjusted for sex, age, pre-existing condition, initial SOFA score, and baseline mHLA-DR; badjusted for covariates in model 2 after PSM
We would like to thank all of the doctors, nurses, technicians, and patients involved at the six participating hospitals for their dedication to the ETASS trial.
Author contributions
FP, YL and JW drafted the manuscript. FP, LZ and LW carried out the data analysis. BG, LL, MC, YN and LW collected and discussed the data. JW, FP and XG designed all research, interpreted data and edited the manuscript. All authors approved the final manuscript as submitted and agreed to be accountable for all aspects of the work.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
The ETASS trial was approved by the ethics committee of the First Affiliated Hospital of Sun Yat-sen University (200815). Written informed consents were obtained from the patients or next of kin.
Consent to participate
Informed consent to participate in the study was obtained from all participants.
Consent to publication
Not applicable.
Availability of data and materials
Requests for accessing the datasets should be directed to contact the corresponding author Prof. Jianfeng Wu. The supplementary tables can be found in the Supplemental materials section.
Funding
This work was funded by Guangdong Clinical Research Center for Critical Care Medicine (2020B1111170005), by Sun Yat-sen University Clinical Research Program 5010 (2007015, 2019002), and by Program for the Natural Science Foundation of Guangdong Province (2016A030313269). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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