Exploration of Immunology

Table 4. Pearson correlations between immunogenetic profiles of 13 P. gingivalis proteins (N = 249 alleles).

Protein	FimB	FimA	FimC	FimD	FimE	Mfa1	Mfa2	Mfa3	Mfa4	Mfa5	RgpA	Kgp
FimB
FimA	0.788
FimC	0.773	0.880
FimD	0.699	0.912	0.904
FimE	0.814	0.924	0.878	0.902
Mfa1	0.818	0.944	0.866	0.888	0.933
Mfa2	0.832	0.875	0.778	0.758	0.841	0.869
Mfa3	0.728	0.893	0.757	0.864	0.869	0.882	0.816
Mfa4	0.43	0.579	0.588	0.631	0.677	0.574	0.53	0.479
Mfa5	0.875	0.949	0.857	0.898	0.929	0.937	0.886	0.912	0.568
RgpA	0.890	0.887	0.876	0.846	0.893	0.886	0.863	0.76	0.657	0.905
Kgp	0.899	0.849	0.787	0.772	0.869	0.876	0.867	0.746	0.665	0.899	0.938
RgpB	0.882	0.872	0.802	0.811	0.899	0.896	0.845	0.772	0.676	0.921	0.939	0.962

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All P-values were highly statistically significant, ranging from 1.65 × 10^–141 to 1.31 × 10^–12. These values Bonferroni-corrected for 78 multiple comparisons, ranged from 1.28 × 10^–139 to 1.01 × 10^–10.

Supplementary materials

The supplementary tables for this article are available at: https://www.explorationpub.com/uploads/Article/file/1003271_sup_1.pdf.

Declarations

Disclaimer

The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.

Author contributions

LMJ: Conceptualization, Investigation, Funding acquisition, Writing—original draft, Writing—review & editing. MS: Data curation, Software, Writing—review & editing. APG: Data curation, Formal analysis, Visualization, Funding acquisition, Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

Apostolos P. Georgopoulos, who is the Editorial Board Member and Guest Editor of Exploration of Immunology, and Lisa M. James, who is the Guest Editor of Exploration of Immunology, had no involvement in the decision-making or the review process of this manuscript. Matthew Sanders declares no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

All data used were retrieved from freely accessible websites and, as such, are publicly and freely available (http://tools.iedb.org/mhci/). Other datasets that support the findings of this study are available from the corresponding author upon reasonable request.

Funding

Partial funding for this study was provided by the University of Minnesota (the American Legion Brain Sciences Chair and the Kunin Chair in Women’s Healthy Brain Aging) and the U.S. Department of Veterans Affairs. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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