From:  Human γδ T cells in colorectal carcinoma: friends or foes

 Antigens recognized by human γδ T cells and main molecules involved in CRC cell-γδ T cell interaction.

Localizationγδ TCR main activatory moleculesTCR ligandMain molecules involved in presentation/activationPutative molecules involved in inhibition
BloodVγ9Vδ2
NKG2D
DNAM-1
HMB-PP, IPP, DMAPP TGM1
hMSH2
BTN2A1, BTN3A1 MR1 MICA/MICB ULBP1-6PD-1 TIGIT
TIM-3
BloodVδ1 NKG2D
DNAM-1
Hsp lipidsCD1a, b, d
MICA/MICB ULBP1-6
PD-1 TIGIT
TIM-3
IntraepithelialVγ4Vδ1 NKG2D
DNAM-1
BTNL3, BTNL8MICA/MICB ULBP1-6PD-1 TIGIT
TIM-3
Lamina propriaVδ1 Vγ9Vδ2
NKG2D
DNAM-1
Hsp
Lipids
pAg
IL23 MICA/MICB
ULBP1-6
PD-1 TIGIT
TIM-3
Tumors, CRC, medulloblastoma
Tissue resident
Vγ9Vδ1EphA2MICA/MICB ULBP1-6PD-1 TIGIT
TIM-3
Tumors
Tissue resident
Vγ8Vδ3
Non-Vγ9Vδ2
MR1
Annexin A2
PD-1 TIGIT
TIM3
Tumors (kidney)Vγ4Vδ5
Non-Vγ9Vδ2
EPCR
Anti-CMV response
CD16PD-1 TIGIT
TIM-3

BTN: butyrophilin; CMV: cytomegalovirus; CRC: colorectal carcinoma; DMAPP: dimethylallyl pyrophosphate; EPCR: endothelial protein C receptor; EphA2: ephrin type-A receptor 2; HMB-PP: (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate; hMSH2: human MutS homologue 2 (DNA mismatch repair enzyme); Hsp: heat shock protein; IPP: isopentenyl pyrophosphate; MICA: MHC class I chain-related protein A; MR1: MHC class I-related protein 1; pAg: phosphoantigen; PD-1: programmed cell death protein 1; TCR: T cell receptor; TGM1: protein-glutamine γ-glutamyl transferase K; TIGIT: T cell immunoreceptor with Ig and ITIM domains; TIM-3: T-cell immunoglobulin and mucin-domain containing-3; ULBP1-6: UL-16 binding proteins 1-6.