Exploration of Immunology

Table 6. Comparison of TLR genes, genotype, and presence of HCMV IgG in the two groups.

HCMV IgG		Groups		Measures
HCMV IgG		Abortion (n, %)	Pregnant (n, %)	P-value	OR (95% CI)
*TLR2*	TT	56 (60.2%)	10 (50.0%)	0.0001^*	5.600 (2.857–10.975)
	TC	34 (36.6%)	8 (40.0%)	0.0001^*	4.250 (1.967–9.181)
	CC	3 (3.2%)	2 (10.0%)	0.657	1.500(0.251–8.977)
	Total	93 (100%)	20 (100%)	-
	X² = 2.054 P < 0.342
*TLR4*	AA	39 (41.9%)	7 (35.0%)	0.0001^*	5.571 (2.492–12.456)
	GA	41 (44.1%)	10 (50.0%)	0.0001^*	4.100 (2.054–8.185)
	GG	13 (14.0%)	3 (15.0%)	0.022^*	4.333 (1.235–15.206)
	Total	93 (100%)	20 (100%)	-
	X² = 0.334 P < 0.894
*TLR7*	AA	62 (66.7%)	10 (50.0%)	0.0001^*	6.200 (3.179–12.091)
	AT	18 (19.4%)	9 (45.0%)	0.090	2.000 (0.899–4.452)
	TT	13 (14.0%)	1 (5.0%)	0.013^*	13.000 (1.701–99.375)
	Total	93 (100%)	20 (100%)	-
	X² = 6.319 P < 0.044^*

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^* Significant differences at P-value < 0.05.

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Declarations

Acknowledgments

The authors would like to extend their sincere thanks to all participants in the research. Especially the staff of Al-Batool Maternity and Children’s Teaching Hospital for facilitating the collection of samples and providing the laboratories.

Author contributions

NMK: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Visualization, Formal analysis. BJAT: Validation, Writing—review & editing, Supervision. AKG: Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The research was approved by the College of Medicine Ethics Committee at the University of Babylon. The collection of samples received approval from the Research and Development Department of the Diyala and Babylon Health Directorates, in accordance with the Ministry of Health letter No. 8199, dated February 12, 2024. This study complies with the Declaration of Helsinki (2024).

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The datasets that support the findings of this study are available from the corresponding author upon reasonable request.

Funding

This research received no external funding.

Copyright

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