Exploration of Immunology

Table 3. Genotyping and allelic frequency association of polymorphism of the TLR2 gene.

(rs3804100) Locus	Abortion			Pregnant		X²	P (HWE)	OR (95% CI)	P- value
(rs3804100) Locus	*TLR2*	n	%	n	%	X²	P (HWE)	OR (95% CI)	P- value
Alleles	T	153	77%	156	78%	0.128	0.720	Ref.
	C	47	23%	44	22%			1.089 (0.682–1.739)	0.721
	Total	200	100%	200	100%			1.089 (0.682–1.739)	0.721
Codominant	TT	57	57%	63	63%	2.292	0.318	Ref.
	TC	39	39%	30	30%			1.437 (0.792–2.607)	0.233
	CC	4	4%	7	7%			0.632 (0.176–2.271)	0.482
	Total	100	100%	100	100%			0.632 (0.176–2.271)	0.482
Dominant	TT	57	57%	63	63%	0.75	0.386	Ref.
	TC-CC	43	43%	37	37%			1.284 (0.729–2.265)	0.387
	Total	100	100%	100	100%			1.284 (0.729–2.265)	0.387
Recessive	TT-TC	96	96%	93	93%	0.866	0.352	Ref.
	CC	4	4%	7	7%			0.554 (0.157–1.954)	0.358
	Total	100	100%	100	100%			0.554 (0.157–1.954)	0.358
Overdominant	TT-CC	61	61%	70	70%	1.792	0.181	Ref.
Overdominant	TC	39	39%	30	30%	1.792	0.181	1.492 (0.83–2.683)	0.182

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HWE: Hardy–Weinberg equilibrium.

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Declarations

Acknowledgments

The authors would like to extend their sincere thanks to all participants in the research. Especially the staff of Al-Batool Maternity and Children’s Teaching Hospital for facilitating the collection of samples and providing the laboratories.

Author contributions

NMK: Conceptualization, Investigation, Writing—original draft, Writing—review & editing, Visualization, Formal analysis. BJAT: Validation, Writing—review & editing, Supervision. AKG: Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

The research was approved by the College of Medicine Ethics Committee at the University of Babylon. The collection of samples received approval from the Research and Development Department of the Diyala and Babylon Health Directorates, in accordance with the Ministry of Health letter No. 8199, dated February 12, 2024. This study complies with the Declaration of Helsinki (2024).

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Not applicable.

Availability of data and materials

The datasets that support the findings of this study are available from the corresponding author upon reasonable request.

Funding

This research received no external funding.

Copyright

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