From:  Genistein as a multi-target therapeutic: translational advances in inflammation and cancer

 Genistein nano delivery systems in cancer therapy.

Nanocarrier typeTargeted cancer typeKey findingsReferences
Self-assembled genistein nanoparticlesGlioblastomaSuppress epithelial-mesenchymal transition by targeting MMP9.[65]
Genistein nanocrystalsGeneral cancer typesImprove aqueous solubility and bioavailability of genistein.[66]
Platelet membrane-coated liposomesLung cancerEnhance targeting and therapeutic efficacy in lung cancer treatment.[67]
TPGS-b-PCL nanoparticlesCervical cancerEnhance the anticancer effect of genistein-loaded nanoparticles.[68]
Different formulations of genistein influence bone mineral status during chemically induced breast cancerBone healthNanogenistein have a negative effect on the amount of calcium in the bone tissue, indicating its increased distribution to the bone.[69]
Anti-CD44-conjugated olive oil liquid nanocapsulesPancreatic cancer stem cellsSelective targeting and increased antitumour efficacy in pancreatic cancer stem cells.[70]
Genistein-loaded transfersomesSkin melanomaDeveloped a novel topical delivery system for skin melanoma treatment.[71]
TPGS-b-PCL nanoparticlesMelanomaPCL-based nanoparticles can enhance the delivery and therapeutic efficacy of genistein in melanoma treatment.[72]
Genistein-loaded biocompatible nanocarriersHematopoietic malignant cellsPromising biocompatible chemotherapeutic agent against hematopoietic malignant cells.[73]
Genistein-chitosan derivative nanoparticlesBreast cancerPotential against breast cancer through active targeting and synergistic treatment strategies.[74]

MMP-9: matrix metalloproteinase-9.