From:  HLA-KIRs interactions in modulating natural killer cell responses against viral hepatitis: a concise review

 Impact of HLA alleles and haplotypes on HBV and HCV outcomes: a global view.

ReferencesYearPopulationFindings
Thio et al. [23]1999African American cohortHLA-II alleles → pathogenesis of HBV infection
Malhotra et al. [22]2001American patientsDRB1*13~DQB1*06 haplotype → improved outcomes with early viral treatment
Thio et al. [24]2003Caucasian individualsHLA-I molecules influence the outcome of HBV infection and may provide insights into HBV pathogenesis
Yu et al. [33]2003Patients in Taiwan, ChinaA direct relationship between the presence of A*11, B*51, Cw*15, and DRB1*15 alleles and a favorable response to IFN-α therapy
DRB1*15~DQB1*05 haplotype was associated with response to IFN-α and A*11~DRB1*15 haplotype was strongly associated with sustained response
Romero-Gómez et al. [34]2003Spanish patientsHLA-B*44—associated with sustained response to IFN-ribavirin in CHC patients
Corghi et al. [30]2008Brazilian patientsAn association between the DRB1*07 allele and the chronicity of HCV infection
Gauthiez et al. [35]2017--An association between DQB1*02, DQB1*03, DRB1*04 and DRB1*11 with spontaneous HCV clearance
Ursu et al. [31]2021Romanian patientsA*23:01, B*44:02, and C*04:02 alleles are linked to an increased genetic predisposition to chronic hepatitis due to HCV
The presence of C*12:02, A*03, and A*11 alleles is associated with the induction of fibrosis grading F3–F4
Ursu et al. [31]2021Romanian patients
Naderi et al. [25]2023Iranian populationDRB1*03:01, DQA1*05:01, DQB1*06:04—associated with increased susceptibility to CHB
DRB1*15:01, DQB1*04:01, DRB1*13:01—protective against CHB
Tălăngescu et al. [36]2024Romanian populationHeterozygosity of HLA-DQB1 and HLA-DRB1 was significantly associated with a lower risk of HBV infection
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CHB: chronic hepatitis B; CHC: chronic hepatitis C; HBV: hepatitis B virus; HCV: hepatitis C virus; HLA: human leukocyte antigen; IFN: interferon.