Exploration of Immunology

Table 4. Some of the ongoing studies on the treatment of acute myeloid leukemia with NK cells.

Study title	NCT number	Interventions	Status	Study type
Haploidentical NK-cell Infusion in Acute Myeloid Leukemia	NCT01947322	Drug: allogenic NK cells infusion	Copleted	Interventional
Cytokine-Induced Memory-Like Natural Killer Cells (CIML-NK) for Relapsed & Refractory Acute Myeloid Leukemia (AML)	NCT05580601	Drug: CIML-NK cells	Recruiting	Interventional
CD123-CD16-NK Cells Immunotherapy for AML	NCT06835140	Drug: donor-derived CD123-CD16 bispecific antibody-modified NK cells	Recruiting	Interventional
Interleukin-21 (IL-21)- Expanded Natural Killer Cells for Induction of Acute Myeloid Leukemia	NCT02809092	Biological: NK cells + chemotherapy starting	Unknown status	Interventional
NK Cells as Consolidation Therapy of Acute Myeloid Leukemia in Children/Adolescents	NCT02763475	Drug: cyclophosphamide Drug: fludarabine Procedure: NK cell infusion	Completed	Interventional
NK Cell Infusion for Remission Consolidation in AML: A Phase II Trial	NCT06783478	Biological: NK cell infusion Other: placebo	Not yet recruiting	Interventional
Safety and Efficacy of Allogenic NK Cells in Combination With Chemotherapy in the Treatment of r/r AML After Allo-HSCT	NCT05744440	Drug: allogenic NK cells	Unknown status	Interventional
NK Cell Infusion for Patients With Acute Myeloid Leukemia	NCT04221971	Drug: chemotherapy combined with NK cell infusion	Unknown status	Interventional
Natural Killer (NK) Cell Transplantation for AML	NCT00187096	Drug: cyclophosphamide, fludarabine, clofarabine, etoposide, interleukin-2 Procedure: NK cell infusion Device: CliniMACS system	Completed	Interventional
Study of Anti-CD33/CLL1 CAR-NK in Acute Myeloid Leukemia	NCT05215015	Biological: anti-CD33/CLL1 CAR-NK cells	Unknown status	Interventional
Expanded Haploidentical Natural Killer Cells as Consolidation Strategy for Children/Young Adults With AML	NCT05334693	Biological: expanded haploidentical NK cells	Recruiting	Interventional
Allogenic CD123-CAR-NK Cells in the Treatment of Refractory/Relapsed Acute Myeloid Leukemia	NCT05574608	Biological: CD123-CAR-NK cells	Unknown status	Interventional
CIML NK Cells With Venetoclax for AML	NCT06152809	Biological: cytokine-induced memory-like natural killer cells Biological: interleukin-2 Drug: venetoclax	Recruiting	Interventional

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Reference from: www.clinicaltrials.gov (accessed August 30, 2025). NK: natural killer.

Declarations

Author contributions

MDG: Conceptualization, Methodology, Formal analysis, Writing—review & editing, Supervision. AP: Conceptualization, Formal analysis, Writing—original draft, Writing—review & editing. GM: Methodology, Writing—review & editing. LdV: Methodology, Formal analysis. FS: Methodology, Formal analysis, Writing—review & editing, Supervision. SG: Conceptualization, Writing—review & editing, Supervision. AA: Conceptualization, Writing—original draft, Writing—review & editing, Supervision. All authors have read and agreed to the published version of the manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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