KK-LC-1: Kita-Kyushu lung cancer antigen-1; MAGE-A3: melanoma antigen family A3; NY-ESO-1: New York esophageal squamous cell carcinoma 1; SSX4: synovial sarcoma, X breakpoint 4; VCX2: variable charge, X-linked 2; VERDI: Vaccine Epitopes Ranked by Digital Intelligence.
Declarations
Acknowledgments
The authors thank Sylva Petrocchi for editorial assistance and R. G. Lisziewicz for contributions to the peptide selection strategy. Language editing support was provided using ChatGPT (OpenAI).
Author contributions
JL: Conceptualization, Methodology, Writing—original draft, Writing—review & editing. JMM: Conceptualization, Writing—original draft, Writing—review & editing. AH: Software. AS: Formal analysis, Software, Visualization. TK: Software, Formal analysis. BGP: Supervision. MBB: Supervision. FL: Validation. CMMC: Resources. AM: Validation. MMV: Investigation. SM: Resources. All authors read and approved the submitted version of the manuscript.
Conflicts of interest
JL is a shareholder of VERDI Solutions GmbH. Authors AS, TK, and AH are employed at VERDI Solutions GmbH. All other authors declare no conflicts of interest.
Ethical approval
The personalized VERDI vaccine was administered under an individual healing attempt protocol in accordance with Article 37 of the Declaration of Helsinki, Version 2013. Approval by an institutional ethics committee was not required under applicable regulations.
Consent to participate
Informed consent to participate in the study was obtained from the participant.
Consent to publication
Not applicable.
Availability of data and materials
The data presented in this study are available upon reasonable request from the corresponding author.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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