From:  Role of immune checkpoint inhibitors in breast cancer and hematological malignancies

 The role of immune checkpoints in hematological malignancies.

ClassificationCheckpoint targetICI drugNotable trial
DLBCLPD-1/PD-L1, CTLA-4, LAG-3, TIM-3, TIGITPembrolizumab, nivolumabNone
PMBCLPD-1/PD-L1, CTLA-4, LAG-3, TIM-3, TIGITPembrolizumabKEYNOTE-013, KEYNOTE-170
HLPD-1/PD-L1, CTLA-4, LAG-3, TIM-3, TIGITNivolumab, pembrolizumabKEYNOTE-087
AMLPD-1/PD-L1, CTLA-4, LAG-3, TIM-3, TIGITAzacitidine, nivolumabNCT02397720
MMPD-1/PD-L1, CTLA-4, LAG-3, TIM-3, TIGITAnti-TIGIT (BMS-986207), Anti-LAG-3 mAb (BMS-980616), pomalidomide, dexamethasoneNCT04150965

ICI: immune checkpoint inhibitor; DLBCL: diffuse large B cell lymphoma; PD-1: programmed death-1; PD-L1: programmed cell death ligand 1; CTLA-4: cytotoxic T lymphocyte-associated protein 4; LAG-3: lymphocyte activation gene-3; TIM-3: T cell immunoglobulin and mucin-domain containing protein 3; TIGIT: T cell immunoreceptor with Ig and ITIM domains; PMBCL: primary mediastinal large B cell lymphoma; HL: Hodgkin lymphoma; AML: acute myeloid leukemia; MM: multiple myeloma.