From:  Role of immune checkpoint inhibitors in breast cancer and hematological malignancies

 Key immune checkpoint molecules in cancer.

Immune checkpointExpressing cellsPrimary ligandFunctionRepresentative inhibitors
PD-1T cells, B cells, NK cellsPD-L1, PD-L2Suppresses T cell activationPembrolizumab, nivolumab
CTLA-4T cellsB7-1, B7-2Inhibits early T cell activationIpilimumab
LAG-3CD4+, CD8+ T cellsMHC-IIPromotes TexRelatlimab
TIM-3CD4+ T cells, macrophagesGalectin-9, CEACAM1Regulates TexSabatolimab
TIGITT cells, NK cellsCD155Suppresses T cell and NK cell activityTiragolumab

PD-1: programmed death-1; NK: natural killer; PD-L1: programmed cell death ligand 1; CTLA-4: cytotoxic T lymphocyte-associated protein 4; LAG-3: lymphocyte activation gene-3; MHC: major histocompatibility complex; Tex: T cell exhaustion; TIM-3: T cell immunoglobulin and mucin-domain containing protein 3; CEACAM1: carcino-embryonic antigen related cellular adhesion molecule 1; TIGIT: T cell immunoreceptor with Ig and ITIM domains.