From:  Eosinophilic granulomatosis with polyangiitis: overcoming diagnostic obstacles and exploring pharmacotherapeutic approaches

 Modern diagnosis and treatment of EGPA.

CategoryDescriptionsReferences
Prognosis
  • Extremely variable; relies on reaction to therapy and organ involvement.

[105, 107, 109, 115118]
  • Overall good with prompt diagnosis and suitable care.

  • A significant contributor to mortality risk is heart involvement.

  • Numerous patients can attain long-term remission.

TreatmentPharmacological interventions:[115, 116]
  • Corticosteroids for the first control, such as prednisone.

  • Immunosuppressive medications (such as methotrexate and cyclophosphamide) for severe conditions.

  • Mepolizumab is one example of a biologic that targets IL-5 in patients who are resistant or relapse.

Non-pharmacological interventions:
  • In extreme, life-threatening circumstances, plasmapheresis handling.

  • Care for concomitant illnesses (such as asthma and hypertension) and monitor for any problems.

Outcomes
  • Increased survival rates when intensive therapy is received early.

[116118]
  • Possibility of a sustained remission for a sizable percentage of patients.

  • Relapse risk, which is frequently controllable with therapy modifications.

  • Some people have a chronic illness that requires constant care.

  • Long-term quality of life and prognosis can be affected by organ disease, particularly cardiac and renal impairment.

  • Side effects of prolonged immunosuppressive medication usage.

EGPA: eosinophilic granulomatosis with polyangiitis.