Table Info

Table 1.

Summary of clinical trials using therapies based on DCs

Method used for tolDCs generation	Clinical trial phase	Target disease	Results	References
ATDCs treated with Dexa	Phase 1	RA	Synovitis decreased Safe and well-tolerated	[78]
Semi-mature DCs treated with Dexa and vitA	Phase 1	Crohn’s disease	Clinical improvement in 1/3 of patients Well-tolerate	[79]
ATDCs treated with vitD3 and pulsed with proinsulin peptide (C19-A3)	Phase 1	T1D	Safe No systemic immunosuppression	[81]
DCs treated with Dexa and vitD3 and pulsed with auto-Ags collected from inflamed synovial joints	Phase 1	RA	Clinical improvement No side effects No systemic immunomodulatory effect	[82]
Semi-mature ATDCs pulsed with 4 Ags related to RA	Phase 1	RA	Good to moderate EULAR score Minimal side effects	[84]
DCs generated in the presence of NF-kB inhibitor and pulsed with RA Ags	Phase 1	RA	Decreased DAS-28 score	[85]

This table presents the various clinical trials using tolDCs to target autoimmune and inflammatory diseases. ATDCs: autologous tolDCs; EULAR: European Alliance of Associations for Rheumatology; DAS-28: disease activity score 28; Dexa: dexamethasone; vitA: vitamin A

Declarations

Author contributions

MEJ: Conceptualization, Project administration, Supervision, Writing—original draft. FS: Conceptualization, Writing—original draft, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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