• 3 results in Exploration of Digestive Diseases
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    Hypoxia signaling and cholesterol/steroidogenic acute regulatory protein 1 axis: interplay and role in alcohol and non-alcohol-related liver diseases
    Metabolic zonation in the liver carries out the maintenance of organ and body homeostasis. Hypoxia is an inherent physiological feature of the liver and contributes to the zonal properties of the he [...] Read more.
    Sandra Torres ... Carmen Garcia-Ruiz
    Published: December 30, 2022 Explor Dig Dis. 2022;1:170–186
    DOI: https://doi.org/10.37349/edd.2022.00012
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    The bile acid receptor TGR5 and cholestasis
    Metabolic zonation in the liver carries out the maintenance of organ and body homeostasis. Hypoxia is an inherent physiological feature of the liver and contributes to the zonal properties of the he [...] Read more.
    Grégory Merlen ... Thierry Tordjmann
    Published: December 30, 2022 Explor Dig Dis. 2022;1:154–169
    DOI: https://doi.org/10.37349/edd.2022.00011
    This article belongs to the special issue CHOLESTASIS
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    Cholestasis associated to inborn errors in bile acid synthesis
    Several metabolic pathways are involved in the biotransformation of C27 neutral cholesterol to C24 primary bile acids (BAs), mainly cholic acid (CA) and chenodeoxycholic acid (CDCA), which are then conjugated with glycine or tauri [...] Read more.
    Ricardo Espinosa-Escudero ... Maria J. Monte
    Published: December 7, 2022 Explor Dig Dis. 2022;1:137–153
    DOI: https://doi.org/10.37349/edd.2022.00010
    This article belongs to the special issue CHOLESTASIS
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