Exploration of Foods and Foodomics

Table 5. Statistically significant phenolic compounds responsible for the differentiation of Retsina samples according to the three parameters under investigation

Factor	Stage examined	Compound	AUC of ROC^※	P-value (t-test)	Log2 fold change^†
Altitude	Intermediate point (stage “a”)	Isorhamnetin	0.89	5.71E-03	–0.71
		Quercetin	0.88	8.42E-03	–0.68
		Gallocatechin	0.77	3.82E-02	–0.34
Tapping method	Maturation and aging	Epicatechin	0.73	1.76E-02	–0.25
		Gallocatechin	0.71	3.54E-02	–0.18
		Caftaric acid	0.70	5.46E-02	–0.09
Contact time	End of fermentation (stage “b”)	Glutathione	1.00	8.02E-05	–1.08
		Isorhamnetin	0.89	4.93E-03	–0.31
		Ethyl caffeate	0.91	7.80E-03	–0.54
		Quercetin	0.91	1.32E-02	–0.32
		Kaempferol	0.84	3.03E-02	–0.26

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※: area under the curve (AUC) of receiver operating characteristic (ROC); †: a negative Log2 fold change indicates a direction towards group of microclimate A for altitude, short extraction time and conventional harvesting

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/101048_sup_1.pdf.

Declarations

Author contributions

AN and CV: Investigation, Methodology, Formal analysis, Writing—original draft, Writing—review & editing. DS: Investigation, Methodology, Formal analysis, Writing—original draft. EK: Conceptualization, Methodology, Resources, Funding acquisition, Project administration. ANA: Resources, Funding acquisition, Project administration, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

All GC-MS data are presented in the Supplementary file in form of peak integrations. All LC-MS integration data are provided in an excel file and can be found here: [https://www.explorationpub.com/uploads/LC-TIMS-TOF_MS_integrations.xls].

Funding

This research has been co‐financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE [T2EDK-03382]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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