Linear: sequential amino acid epitopes independent of protein folding; conformational: discontinuous epitopes dependent on three-dimensional protein structure; both: IgE-binding to both epitope types reported in the literature. IgE: immunoglobulin E; IgG: immunoglobulin G; HEL: Hen Egg Lysozyme.
Declarations
Acknowledgments
During the preparation of this work, the authors used PaperPal Advanced AI for grammar and clarity checking. Elicit for literature search, and Claude (Anthropic) for manuscript revision and structural reorganization. After using these tools, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.
Author contributions
PS: Conceptualization, Methodology, Supervision, Resources, Project administration, Formal analysis, Writing—review & editing, Visualization. YW: Investigation, Software, Writing—original draft, Visualization. VR: Supervision, Funding acquisition, Resources, Formal analysis, Project administration, Conceptualization. The authors have read and approved the submitted version.
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