Table Info

Table 2.

Percentage of patients with severe asthma sensitized according to protein families

Protein family	STO (n = 47)	VAL (n = 29)	P
Component	STO (n = 47)	VAL (n = 29)	P
LTPs
nPru p 3	6.4	27.6	0.02
rPar j 2	2.1	27.6	0.002
nArt v 3	8.5	17.2	0.29
rCor a 8	2.1	10.3	0.15
Tropomyosins
nPen m 1	4.3	41.4	< 0.001
rDer p 10	6.4	41.4	< 0.001
nBla g 7	4.3	41.4	< 0.001
rAni s 3	4.3	41.4	< 0.001
Prophyllines
rBet v 2	10.0	3.5	0.40
rPhl p 12	8.5	3.5	0.64
rHev b 8	10.6	3.5	0.40
CCDs
nCup a 1	10.6	44.8	0.002
nCry j 1	4.3	31.0	0.002
nPla a 2	8.5	34.5	0.007
nPhl p 4	38.3	34.5	0.81
Uteroglobin
rFel d 1	72.3	37.9	0.004
Lipocalins
rFel d 4	29.8	20.7	0.43
rCan f 1	25.6	48.3	0.05
rCan f 2	17	13.8	1
Serum albumins
nFel d 2	2.1	20.7	0.01
nCan f 3	6.4	6.9	1
nEqu c 3	4.3	10.3	0.36
Storage proteins
rAna o 2	4.3	0	0.52
nAra h 1	38.3	6.9	0.003
nAra h 2	27.7	6.9	0.04
nAra h 3	25.5	6.9	0.01
rBer e 1	4.3	0	0.52
nCor a 9	14.9	10.3	0.73
nGly m 5	10.6	3.5	0.40
nGly m 6	17	6.9	0.14
nSes i 1	8.5	0	0.29
PR-10 proteins
rBet v 1	57.5	3.5	< 0.001
Pru p 1	44.7	3.5	< 0.001
rGly m 4	19.2	3.5	0.08
rAra h 8	23.4	0	0.005
rApi g 1	12.8	0	0.08
rCor a 1.0101	36.2	0	< 0.001
rCor a 1.0401	44.7	3.5	< 0.001
rMal d 1	33.3	3.5	< 0.001
Cysteine protease
nAct d 1	14.9	10.3	0.73
Thaumatin-like
nAct d 2	8.5	31.0	0.025
Kiwellin
nAct d 5	2.1	0	1
Alt a 1-related
rAlt a 1	14.9	37.9	0.028
Enolase
rAlt a 6	8.5	31.0	0.025

nArt v 3: Artemisia vulgaris allergen 3; nCry j 1: Cryptomeria japonica allergen 1; nEqu c 3: Equus caballus allergen 3; nSes i 1: Sesamum indicum allergen 1; rAna o 2: Anacardium occidentale allergen 2; rBer e 1: Bertholletia excelsa allergen 1; rHev b 8: Hevea brasiliensis allergen 8

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/100919_sup_1.pdf.

Declarations

Acknowledgments

We gratefully thank the collaboration of ThermoFisher Scientific. This work was also supported by the Freemason Child House Foundation in Stockholm, the Consul Th. C. Bergh’s Foundation, the Swedish Asthma and Allergy Association’s Research Foundation, the Centre for Allergy Research at Karolinska Institutet, the Swedish Heart‐Lung Foundation, the Swedish Research Council, Region Stockholm (ALF-project), and the Swedish Cancer and Allergy Foundation.

Author contributions

JMG: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Visualization, Writing—original draft, Writing—review & editing. JRK: Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Writing—review & editing. GH: Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing—review & editing. MvH: Formal analysis, Investigation, Methodology, Supervision, Validation, Writing—review & editing. ANG: Conceptualization, Methodology, Resources, Supervision, Writing—review & editing. MNC and SU: Data Curation, Resources, Supervision, Writing—review & editing. AM: Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Supervision, Visualization, Writing—original draft, Writing—review & editing.

Conflicts of interest

Dr. van Hage reports personal fees from Thermo Fisher Scientific outside the submitted work. Dr. Konradsen has received research support from Thermo Fisher Scientific outside the submitted work.

Ethical approval

The study was approved by the Ethics Committee from Hospital La Fe-Comité de Ética de la Investigación con medicamentos (Registry number 2020-005-1) and sheltered by the regional board of ethics at Karolinska Institutet (Registry number Dnr 2006/1324-31/1 and 2008/378) and was conducted in accordance with the Declaration of Helsinki.

Consent to participate

The informed consent to participate was waived by the Ethics Committee from Hospital La Fe-Comité de Ética de la Investigación con medicamentos since the data collected for the study was retrospective.

Consent to publication

Not applicable.

Availability of data and materials

All data generated or analysed during this study are included in this article or its Supplementary materials. Further enquiries can be directed to the corresponding author (jaume.marti.garrido@gmail.com).

Funding

This project has been granted awards from Sociedad Española de Alergología e Inmunología Clínica (SEAIC), Asociación Valenciana de Alergia e Inmunología Clínica (AVAIC) and Colegio Oficial de Médicos de Valencia (COMV). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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