Type IV hypersensitivity reaction; herpes virus reactivation; cytokine dysregulation
2–8-week latency; fever, fatigue, and diffuse lymphadenopathy; morbilliform rash affecting the face and leading to facial edema; palms and soles usually spared; eosinophilia
Type IV hypersensitivity reaction; granulysin-mediated keratinocyte apoptosis
Rapidly progressive irregular purpuric macules that progress to bullae with widespread epidermal necrolysis; painful erosions of the mucus membranes; positive Nikolsky sign
Fulminant type 1 diabetes mellitus (FT1DM), thyroiditis, SLE, Sjögren’s syndrome, ANA seroconversion
AGEP
Type IV hypersensitivity reaction; IL-8-neutrophil recruitment
24–48-hour latency after exposure; sterile, pruritic, non-follicular pustules that spare the mucosal membranes; elevated neutrophilia
No clear link; however, some associations with CARD 14 mutations and polyarteritis nodosa
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