From:  Current approach to the diagnostic value of aspirin provocation tests in nonsteroidal anti-inflammatory drug exacerbated respiratory disease: indications, methodology, safety, and clinical applications

 Oral aspirin provocation test protocol.

StepAspirin doseTime after previous dose
120–40 mg*60–90 minutes
260–80 mg60–90 minutes
3100 mg60–90 minutes
4160–325 mg (final dose)60–90 minutes

Total cumulative dose: ~340–545 mg, depending on the last step. Observation after final dose: at least 2 hours. * In high-risk patients, lower doses of aspirin can be introduced.