From:  Real-life effectiveness of mepolizumab on remission and chronic rhinosinusitis with nasal polyps in severe eosinophilic asthma

 The multivariate regression analysis was conducted to further assess the independent predictors of remission, also comparing the remission and non-remission groups.

ParametersMultivariate regression analysis
Average95% CIp value
Model-1*
Number of emergency service visits before treatment0.7170.550–0.9340.014
Pre-treatment eosinophil count1.0011.000–1.0010.099
Model-2**
Pre-treatment FEV1 (%)1.0381.005–1.0730.025
Prior omalizumab use0.3310.113–0.9670.043
Model-3***
Pre-treatment FEV1 (%)1.0351.003–1.0690.033
Prior omalizumab use0.3060.106–0.8850.029
Model-4****
Pre-treatment FVC (%)1.0351.002–1.0690.038
Prior omalizumab use0.3020.104–0.8770.028
Model-5*****
Pre-treatment FVC (%)1.0321.000–1.0650.047
Prior omalizumab use0.2820.098–0.8080.018

p-values represent independent associations between selected variables and remission status after adjustment in multivariate logistic regression. Variables that were statistically significant in the univariate analysis and not collinear were included in the multivariate models. Bolded p-values indicate statistical significance (p < 0.05). FEV1: forced expiratory volume in 1 second; FVC: forced vital capacity.