ENTPDase inhibitors—monoclonal antibodies

AntibodiesInhibition potentialSpecificityApplicationExperimental context
hN3-B3S or hN3-H10S
[90]
76–77%hNTPDase3Potential for the treatment of type 2 diabetes through insulin secretion modulation and application as a research toolInhibition assays in hNTPDase3 and in pancreatic islet cells (Langerhans cells)
hN2-D5S
[89]
50%hNTPDase2Tools for studying NTPDase2 (expression and function), therapeutic potential in cancer, and regulation of intestinal motilityEnzymatic assays using malachite green, specificity evaluated by western blot, flow cytometry, and immunocytochemistry
Anti-hNTPDase8
[88]
No inhibition of NTPDase8 activityhNTPDase8Tools for the localization and study of NTPDase8 function in human and murine tissuesEnzymatic assays using malachite green, specificity evaluated by western blot, flow cytometry, and immunocytochemistry

ENTPDase: ectonucleoside triphosphate diphosphohydrolase