Examples of pathogen E-NTPDases in infectious diseases and the purinergic signaling associated with each disease

PathogenENTPDasePurinergic signalingInfectious diseaseReferences
Toxoplasma gondiiTgNTPDase1, TgNTPDase2Reduces P2X7 activation, promotes P1-A2A activation in the hostToxoplasmosis[4146]
Trichomonas vaginalisTvNTPDase1, TvNTPDase2Activates P1-A2A receptor in the hostTrichomoniasis[44, 45]
Leishmania spp.LdNTPDase1, LdNTPDase2Reduces P2X7 activation and promotes P1-A2 receptor activation in the hostLeishmaniasis[36, 49, 50]
Trypanosoma cruziTcNTPDase1Activates P1-A2 receptors in the hostChagas disease[36, 5255]
Plasmodium falciparumE-NTPDase (PF3D7_1431800)Activates P1 receptors in the host, expresses PfENT1 transporter and G protein-coupled receptors (GPCRs)Malaria[5558]
Schistosoma mansoniSmATPDase1, SmATPDase2Increased expression of NTPDase2, NTPDase3, and P2Y1 receptors; reduced P2X7 receptor in the hostSchistosomiasis[37, 6063]

ENTPDase: ectonucleoside triphosphate diphosphohydrolase