Cells of the vascular adventitia, microvascular pericytes, subendocardial space, portal fibroblasts, astrocytes, taste buds, and neural precursor cells
There is no clear preference between Ca2+ and Mg2+. High preference for ATP over ADP (preferential ecto-ATPase). Km for ATP: 70 μM
Regulation of vascular hemostasis. Involvement in controlling neurogenesis and neural differentiation. Role in taste information transmission from taste buds to gustatory nerves. Modulation of portal fibroblast proliferation.
Hypocretinergic neurons, sensory neurons, islets of Langerhans, and renal and reproductive epithelia
Preference for Ca2+ and ATP over ADP. Km for ATP: 75 μM
Modulation of purinergic neurotransmission, regulation of nociceptive circuits, involvement in the development of circadian rhythms in the hypothalamus, and role in energy metabolism.
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
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Availability of data and materials
Not applicable.
Funding
The authors gratefully acknowledge the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for the fellowship grants awarded to JLRF and ICR, which supported this study. This study was sponsored in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) [001]; Fundação de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) [BPD-00498-22]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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