KIR and HLA-C combination and RPLs

ReferencesAA/Bx frequencyKIRKIR/HLA combination
Yang et al. [183]No differenceNo differenceKIR2DL2 with maternal C2; a higher risk
Dambaeva et al. [179]No differenceNo differenceKIR2DS1 with maternal C2; a higher risk
Alecsandru et al. [187]AA type has a higher risk of miscarriage after DET vs. AB or BB haplotypes
No difference in SET		No differenceNo paternal or egg donor study
Wang et al. [188]-Decreased KIR2DL1/S1-
Ozturk et al. [184]Increased Bx genotypeNo difference-
Faridi et al. [185]No differenceNo DifferenceKIR2DL1 with both partners HLAC2/C2; decreased risk
KIR2DS2 with both parent’s HLA C1/C1; increased risk
Nowak et al. [189]No differenceNo differenceHLA-C1C2 women with KIR AA and HLA C2C2 partners, the trend towards increased chances of a successful pregnancy
Hiby et al. [177]--KIR AA women; increased risk only when the fetus has more C2 than the mother
Faridi et al. [190]Increased BB genotypeNo difference-
Vargas et al. [191]-Increased (5 or 6 out of 6) activating KIR repertoire in women with RPL. No difference in gene frequency-
Hiby et al. [192]AA genotype increaseKIRS2DS1 decreaseHLA-C2 increase
Hong et al. [193]No differenceKIR2DL2 increaseNo difference
Wang et al. [194]-KIR2DS1 increaseKIR2DS1 negative women with decreased HLAC2
Flores et al. [195]AA genotype increaseKIR2DL2 decrease-

DET: double ET; SET: single ET