Table Info

Table 1.

Associated clinical trials of γδ T cells immunotherapy

Clinical trial identifier	Phase	Start date	Status	Cancer type	Interventions	Outcome measures
NCT01404702	I	August, 2011	Terminated	Neuroblastoma	ZOL, IL-2	Safety, tumor response, etc.
NCT00582790	II	August, 2003	Terminated	Kidney cancer	ZOL, IL-2	OS, PFS, safety, etc.
NCT02781805	I	August, 2016	Terminated	Breast neoplasms	ALD	Percentage change of γδ T cells
JPRN-UMIN000008097	I	June, 2017	Not recruiting	Esophageal cancer	Autologous γδ T cells	Safety, PFS, OS, etc.
JPRN-UMIN000007878	II	May, 2012	Not recruiting	MM	Autologous γδ T cells	TTP, PFS, safety, etc.
JPRN-C000000336	I, II	March, 2006	Not recruiting	NSCLC	Autologous γδ T cells	Safety, PFS, QOL, etc.
JPRN-UMIN000006128	II	August, 2011	Not recruiting	NSCLC	ZOL-expanded autologous γδ T cells	PFS, QOL, safety, etc.
NCT03790072	I	November, 2018	Completed	AML	Allogeneic γδ T cells	Safety, DLT, CR, etc.
NCT04008381	I	September, 2019	Recruiting	AML	Allogeneic γδ T cells	RR, safety, OS, etc.
NCT04518774	I	August, 2020	Recruiting	Hepatocellular carcinoma	Allogeneic γδ T cells	Safety, DLT, QOL, etc.
NCT04735471	I	March, 2021	Recruiting	Lymphoma	Allogeneic γδ T cells	DLT, OS, PFS, etc.
NCT04165941	I	February, 2020	Recruiting	Brain tumor adult	DRI modified γδ T cells	DLT, safety, TTP, etc.
NCT03533816	I	January, 2020	Recruiting	Leukemia, MDS	Allogeneic γδ T cells	DLT, safety, RFS, etc.
NCT04911478	-	August, 2021	Enrolling by invitation	Lymphoma	Allogeneic γδ T cells	Safety, ORR, PFS, etc.
NCT05015426	I	August, 2021	Recruiting	AML	aAPC-expanded γδ T cells	MTD, RFS, OS, etc.
NCT05001451	I	August, 2021	Recruiting	AML	Allogeneic Vδ1⁺ γδ T cells	Safety, DLT, etc.
NCT00562666	I	February, 2008	Terminated	Hepatocellular carcinoma	γδ T cells	Safety, tumor response
JPRN-UMIN000028370	II	July, 2017	Recruiting	AL, lymphoma, solid tumor	Autologous γδ T cells, nucleoside (acid) analogues	DFS
NCT04107142	I	December, 2019	Unknown status	Colorectal cancer, TNBC, Sarcoma, nasopharyngeal Carcinoma, PC, GC	NKG2DL-targetting CAR-grafted γδ T cells	DLT, safety, PFS, etc.
NCT05302037	I	April, 2022	Not yet recruiting	Cancer	NKG2DL-targetting CAR-grafted γδ T cells	DLT, safety, PFS, etc.
NTR6541	I	January, 2017	Recruiting	AML, MDS, MM	TEG001	DLT
NCT04688853	I	May, 2021	Recruiting	MM	TEG002	Safety, DLT, OS, etc.

aAPC: artificial APC; AL: acute leukemia; AML: acute myeloid leukemia; CAR: chimeric antigen receptor; CR: complete remission; DFS: disease free survival; DLT: dose-limiting toxicities; DRI: drug resistant immunotherapy; GC: gastric cancer; MDS: myelodysplastic syndromes; MM: multiple myeloma; MTD: maximum tolerated dose; NSCLC: non-small cell lung cancer; ORR: objective response rate; OS: overall survival; PC: prostate cancer; PFS: progression-free survival; QOL: quality of life; RFS: relapse-free survival; RR: relative risk; TEG: T cell engineered to express a defined γδ TCR; TNBC: triple-negative breast cancer; TTP: time to progression

Declarations

Author contributions

JZ and XJ wrote the initial draft of the manuscript; JZ prepared the figure; HZ and WW organized literature for manuscript; XW and ZJ revised the final draft. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This study was supported in part by grants from the National Natural Science Foundation of China (Nos. 81800143, 81770150, 81200388, and 82170220), Natural Science Foundation of Guangdong Province (No. 2020A1515010817 and 2022A1515010313), the Science and Technology Program of Guangzhou City (No. 202201010164), National Innovation and Entrepreneurship Training Program for Undergraduate (No. 202010559081), Guangdong’s Innovation and Entrepreneurship Training Program for Undergraduate (Nos. 202010559081 and 202210559083), “Challenge Cup” National Undergraduate curricular academic science and technology works by race (No. 21112027) and Guangdong College Students’ Scientific and Technological Innovation (Nos. CX22438, CX22446, and CX21285). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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