Table Info

Table 2.

Active adoptive γδ T-cell immunotherapy clinical trials against hematologic malignancies

ClinicalTrials.gov identifier	Sponsor	Disease	Intervention	Phase	Status
NCT04696705	Institute of Hematology & Blood Diseases Hospital	NHL and PTCL	Ex vivo expanded allogeneic γδ T cells	Early Phase I	Recruiting
NCT05015426	H. Lee Moffiff Cancer Center and Research Institute	AML	Ex vivo expanded donor γδ T cells post allo-HSCT	Phase I/Ib	Recruiting
NCT04764513	Chinese PLA General Hospital	AML, ALL, MDS, lymphoma	Ex vivo expanded donor γδ T cells post allo-HSCT	Phase I/II	Recruiting
NCT03533816	University of Kanas Medical Center	AML, CML, ALL, MDS	EAGD T-cell infusion following haplo-HSCT	Phase I	Recruiting
NCT05001451	GammaDelta Therapeutics Limited	AML	GDX012 infusion–allogeneic Vδ1⁺ γδ T cells	Phase I	Recruiting
NCT04008381	Wuhan Union Hospital	AML	Ex vivo expanded allogeneic γδ T cells from suitable donor	Phase I	Recruiting
NCT03790072	TC Biopharm	AML	Ex vivo expanded allogeneic γδ T cells from suitable donor (OmnImmune^®)	Phase I	Completed
NCT04702841	PersonGen BioTherapeutics	CD7⁺ T-cell malignancies	CAR–γδ T cells	Early Phase I	Recruiting
NCT04735471	Adicet Bio. Inc.	B-cell malignancies	Anti-CD20-CAR-T	Phase 1	Recruiting

PTCL: peripheral T-cell lymphoma; MDS: myelodysplastic syndrome; CML: chronic myeloid leukemia; EAGD: ex vivo expanded/activated γδ; haplo: haploidentical

Declarations

Author contributions

NJ and SSR both wrote the first draft, edited, read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by the K08CA248962 grant (S.S.R.) from the National Cancer Institute (NCI) of the National Institutes of Health (NIH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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