Table Info

Table 1.

Murine models: γδ T cells in AT and adiposity

Study	IL-17⁺ γδ T cells	IFNγ⁺ γδ T cells	Number/functions	Reference
γδ T cells in AT	Present		Inhibition of adipogenesis	[31]
γδ T cells in AT	Present		Induction of IL-33 production; γδ T cells are responsible for non-shivering thermogenesis	[32]
γδ T cells in AT	Present		Binds to the IL-17RC, increases sympathetic innervation	[33]
γδ T cells in AT, effect of KD			Short term KD increases anti-inflammatory γδ T cells, long term-induces obesity and depletes γδ T cells in AT	[34]
IEL γδ T cells			Express GLP-1R, forming a “depleting sink” for GLP-1R, thus possibly contributing to obesity	[35]
γδ T cells in AT-effect of HFD induced obesity			HFD increased γδ T cells in inguinal fat	[36]
γδ T cells in AT-effect of HFD induced obesity			HFD increased γδ T cells. AT was decreased in the absence of leptin	[37]
γδ T cells in AT-effect of HFD in TL1A deficient mice			TL1A deficient mice were less obese and had fewer γδ T cells in AT	[38]
Subsets of γδ T cells in AT, effect of HFD	Present, mainly Vγ4 and 6⁺		HFD induces an increase of CD44⁺CD62lo γδ T cells in epididymal fat which appear to play a proinflammatory role	[39]
Effect of a transgene PPAR-β expressed in T cells on HFD and IR			Mice bearing Tg T-PPAR-β in T cells have depleted αβ T cells and no change in γδ T cell number resulting in an increased γδ/αβ T cell ratio in lymphoid organs and preserved γδ T cells in WAT. These mice have less IR and are less obese	[40]
Hyperglycemic obese mice			Reduced skin γδ cells dysfunctional in keratinocyte repair	[42–44]
Effect of HFD on imiquimod induced psoriasis			More γδ low cells expressing PD1 in the skin	[45]
Obesity-related to adiponectin deficiency in psoriasis	Elevated in the skin by obesity		Reduced by adiponectin	[46]
Effect of HFD on Corynebacterium activated skin γδ T cells	Elevated in the skin by HFD			[47]
Effect of obesity on ozone induces lung changes			Increase of IL-13⁺ and ST2 related IL-33 responsive γδ T cells in the lung	[48]
Effect of obesity on γδ T cells in the lung	Elevated by HFD in the lung		Increased airway hyperresponsiveness	[49]
Effect of HFD on gut T cells			IEL, which express GLP-1R, CD69, and CD103 are decreased by HFD, leading to increased sensitivity to dextran sulfate-induced colitis	[50–52]
Deficiency of integrin β7-effect on HFD			Decreased GLP-1R⁺ γδ and αβ IEL, leading to resistance to HFD causing obesity, due to decrease of GLP-1R	[35]
Effect of obesity on ocular T cells in NRF2^–/^– mice (model for AMD)	Increased in the eye		Induction of retinal lesions	[53]
A high cholesterol diet in mice			Reduced number of γδ T cells in the thymus, colonic submucosa, and early tumorogenesis	[54]
Effect of 27-hydroxycholesterol			An increase in the number of polymorphonuclear neutrophils and pro tumoral γδ T cells at distal metastatic sites	[55]
Diet-induced obesity			CCR6⁺ pro-tumoral γδ T cells attracted to chemically induced colon adenocarcinoma	[56]
Metabolic characteristics of pro and anti-tumoral γδ T cells and effect of the obesity	IL-17 producing cells are dependent upon oxidative phosphorylation, exhibit high lipid uptake and increase in obesity	IFNγ producing γδ T cells are dependent upon glycolysis	IL-17⁺ γδ T cells were pro-tumoral, whereas IFNγ⁺ cells were anti-tumoral	[57]

GLP-1R: glucagon-like peptide-1 receptor; PD1: programmed death 1; NRF2: nuclear erythroid 2-related factor 2; AMD: age-related macular degeneration; CCR6: C-C motif chemokine receptor 6

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