Table Info

Table 1.

Most frequent viruses causing respiratory tract infections

Virus	Sub-types	Effect on cGAS-STING and host defense
Adenovirus	55 serotypes	Inhibited by viral proteins activated when bound to antibodies
Bocavirus	1 serotype	No direct effect reported inhibited TNF-α, NFκB, IFN-β
Coronavirus	α (NL63, 229E) β (HKU1, MERS, SARS)	Cell type specific epithelium: inhibited STING, IRF3 T-/B-cells: activated cGAS via cGAMP
Influenzavirus	A (H1–3, N1–2), B, C	Activated cGAS, STING, IFN-β
Metapneumovirus	A, B	No report
Parainfluenzavirus	4 serotypes	Activated STING
Rhinovirus	A, B, C (> 100 serotypes)	Activated cGAS, STING, IFN-β
RSV	A, B	Activated cAMP, IFN-β

TNF-α: tumor necrosis factor-alpha; MERS: Middle East respiratory syndrome; cAMP: cyclic adenosine monophosphate

Declarations

Author contributions

LF and MR both wrote the first draft, edited, read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

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Consent to publication

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Availability of data and materials

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Funding

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Copyright

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