Table Info

Table 2.

Sequence alignment of viral/bacterial mimicry peptides that stimulate MBP-specific T cell clones that are DQ1 or DR2 restricted [9]

Peptides recognized by clone Hy.1B11 (DO1 restricted)

MBP(85–99)

Herpes simplex, UL15 protein

Adenovirus type 12, ORF

Pseudomonas, phosphomannomutase

Human papillomavirus type 7, L2 protein

Peptides recognized by clone Hy.1G11 (DR2 restricted)

MBP(85–99)

EBV, DNA polymerase

Influenza type A, hemagglutinin

Reovirus type 3, sigma 2 protein

Peptides recognized by clone Hy.1G11 (DR2 restricted)

MBP(85–99)

EBV, DNA polymerase

Influenza type A, hemagglutinin

Herpes simplex, DNA polymerase

ORF: open reading frame; EBV: Epstein-Barr virus

Note. Reprinted from “Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein” by Wucherpfennig KW, Strominger JL. Cell. 1995;80:695–705 (https://www.cell.com/cell/pdf/0092-8674(95)90348-8.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2F0092867495903488%3Fshowall%3Dtrue). © 1995, Cell Press.

Declarations

Acknowledgements

I thank Dr. Leonardo MR Ferreira for his invaluable feedback and Sarah Cannon for her editorial assistance. This article is dedicated to the memory of Mark Veksler and Pinhas Bratshpis who died of COVID-19.

Author contributions

The author contributed solely to the work.

Conflicts of interest

The author declares that he has no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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