Exploration of Immunology

Table 6. Evaluation of PSSM and ANN predictors on the SARS-CoV-2 dataset of Gfeller et al. [50] using threshold (cutoff score) and % rank measure analysis in the source protein.

S. No.	CD8+ T cell epitope	Source protein (SWISS-PROT accession no.)	HLA binding allele	PSSM predictor		ANN predictor
S. No.	CD8+ T cell epitope	Source protein (SWISS-PROT accession no.)	HLA binding allele	Score	% rank	Score	% rank
1	LYLYALVYF	AP3A (P0DTC3)	A*2402	9.218	0.75	0.418	13.48
2	LWLLWPVTL	VME1 (P0DTC5)	A*2402	8.366	1.4	0.402	22.43
3	LPPAYTNSF	SPIKE (P0DTC2)	B0702, B3501, B*5301	9.718, 10.505, 9.574	0.32, 0.24, 0.87	0.457, 0.447, 0.495	2.21, 19.37, 6.56
4	FTSDYYQLY	AP3A (P0DTC3)	A0101, A2402, A*2902	14.473, 2.999, 11.658	0.37, 16.48, 0.37	0.491, 0.326, 0.540	34.08, 46.81, 22.47
5	YFPLQSYGF	SPIKE (P0DTC2)	A*2402	7.166	1.42	0.38	34.78
6	SASKIITLK	AP3A (P0DTC3)	A0301, A1101	6.574, 5.973	2.25, 1.9	0.672, 0.790	0.37, 0.37

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PSSM: position-specific scoring matrices; ANN: artificial neural networks.

Supplementary materials

The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/1003215_sup_1.pdf.

Declarations

Acknowledgments

The authors are thankful to Prof. Brijesh Pandey, Mahatma Gandhi Central University, Motihari, for the valuable suggestions in revising the manuscript.

Author contributions

SPS: Conceptualization, Methodology, Investigation, Writing—review & editing. GS: Data curation, Investigation. BNM: Supervision, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Supplemental information can be found online at https://data.mendeley.com/datasets/dxz3dk3tcm/1 at Mendeley data (DOI: 10.17632/dxz3dk3tcm.1). Data are licensed under an Attribution-NonCommercial 3.0 Unported licence. All figures in the study were created using the MS-Excel program.

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