Cardiac performance, status of RAS, oxidative stress and subcellular activities in 8 weeks diabetic rats with or without ENP and LOS treatments
Parameters
Control
Diabetic
Diabetic + ENP
Diabetic + LOS
A. Cardiac function parameters
LVSP (mm Hg)
140 ± 12.1
85 ± 8.4*
119 ± 7.6†
116 ± 6.9†
+ dP/dt (mm Hg/sec)
8856 ± 815
5380 ± 621*
7176 ± 702†
7044 ± 516†
B. RAS activities
Plasma ANG II (fmol/ml)
7.2 ± 0.8
7.4 ± 0.5
6.4 ± 0.6
10.9 ± 0.4†
Plasma ACE activity (nmol/min per ml)
48 ± 2.5
52 ± 3.1
49 ± 3.5
57 ± 2.6
LV ACE activity (nmol/min per mg)
0.57 ± 0.03
0.89 ± 0.04*
0.56 ± 0.3†
0.79 ± 0.03
C. Oxidative stress levels
LV GSH/GSSG Ratio
6.8 ± 0.4
2.5 ± 0.2*
4.3 ± 0.5†
4.8 ± 0.2†
MDA content (nmol/mg tissue lipids)
3.8 ± 0.13
7.1 ± 0.49*
4.9 ± 0.46†
5.4 ± 0.48†
D. Myosin ATPase activities
Mg2+-ATPase (nmol Pi/mg per 5 min)
1.2 ± 0.03
0.78 ± 0.07*
1.06 ± 0.05†
1.00 ± 0.06†
Ca2+-ATPase (nmol Pi/mg per 5 min)
6.22 ± 0.18
3.14 ± 0.21*
4.91 ± 0.23†
4.86±0.28†
E. SL activities
Na+-K+-ATPase (μmol Pi/mg per h)
23.2 ± 3.5
13.1 ± 1.8*
18.2 ± 1.6†
18.3 ± 1.5†
Na+-Ca2+-exchanger (nmol Ca2+/mg per 10s)
21.3 ± 1.2
12.1 ± 0.9*
17.3 ± 1.2†
16.1 ± 1.5†
F. SR activities
Ca2+-stimulated ATPase (nmol Pi/mg per 5 min)
165 ± 7
115 ± 10*
154 ± 5†
153 ± 6†
Ca2+-uptake (nmol Ca2+/mg per 2 min)
62.7 ± 2.3
36.5 ± 3.1*
50.3 ± 2.1†
53.4 ± 2.7†
Values are mean SE of 6 to 8 animals in each group. Data are based on the analysis of the information in Tables 1 and 2 in our paper Liu et al. Ann. N.Y. Acad Sci. 2006;1084:141–54 [174] and Figures 1A, 3B, 5A and 6A in our paper Machackova et al. Mol Cell Biochem. 2004;261:271–8 [175]. *Significantly different (P < 0.05) from control; †Significantly different (P < 0.05) from untreated diabetic
Declarations
Acknowledgments
The infrastructure support for this project was provided by the St. Boniface Hospital Research Foundation, Winnipeg, Canada. Thanks are also due to Ms. Andrea Opsima for typing this manuscript.
Author contributions
SKB searched the literature, analyzed the data and wrote the first draft; AKS analyzed the data and wrote the manuscript; NSD conceived, designed and edited the article. All authors have read and agreed to the published version of the manuscript.
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