Cardiac dysfunction, cardiac remodeling and alterations in protein content of phospho- ERK1, ERK2 and ELK1 in rats following the induction of heart failure by VO with or without ENP and LOS treatment for 16 weeks
Parameters
Control
VO
VO + ENP
VO + LOS
A. Cardiac remodeling
Heart wt (mg)
1364 ± 41
2209 ± 117*
1671 ± 97†
1526 ± 105†
LV wt (mg)
1067 ± 29
1640 ± 142*
1217 ± 61†
1119 ± 66†
RV wt (mg)
300 ± 13
554 ± 42*
462 ± 25†
394 ± 36†
HW/BW ratio (mg/g)
2.23 ± 0.13
3.37 ± 0.14*
2.68 ± 0.14†
2.47 ± 0.17†
B. Phospho-ERK1 and phospho-ERK2 content as well as ERK1/ERK2 activity
Phospho-ERK1 (% of control)
100
552 ± 81*
309 ± 40†
127 ± 40†
Phospho-ERK2 (% of control)
100
572 ± 52*
312 ± 26†
131 ± 30†
Phospho-ELK1 (% of control)
100
777 ± 28*
144 ± 21†
87 ± 28†
C. Cardiac function
LVSP (mm Hg)
115 ± 5
85 ± 2*
91 ± 6
93 ± 7
LVEDP (mm Hg)
5.2 ± 1.4
28.0 ± 1.9*
18.6 ± 1.5†
13.8 ± 0.6†
+ dP/dt (mm Hg/sec)
10,000 ± 429
4752 ± 240*
6995 ± 364†
7989 ± 88†
− dP/dt (mm Hg/sec)
10,208 ± 511
4724 ± 259*
7638 ± 380†
8068 ± 409†
Values are mean ± SE of 8 hearts in each group. VO: volume overload; LV wt: left ventricular weight; RV wt: right ventricular wt; BW: body weight; HW: heart weight. Data are based on the analysis of the information in Table 2 and Figures 3, 4 and 5 in our paper Zhang et al. J Cardiovasc Pharmacol Ther. 2010;15:84–92 [168]. *P < 0.05 compared with control; †P < 0.05 compared with VO group
Declarations
Acknowledgments
The infrastructure support for this project was provided by the St. Boniface Hospital Research Foundation, Winnipeg, Canada. Thanks are also due to Ms. Andrea Opsima for typing this manuscript.
Author contributions
SKB searched the literature, analyzed the data and wrote the first draft; AKS analyzed the data and wrote the manuscript; NSD conceived, designed and edited the article. All authors have read and agreed to the published version of the manuscript.
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